Structure of PDB 8c0w Chain E

Receptor sequence

>8c0wE (length=1030) Species: 4932 (Saccharomyces cerevisiae)

MKASLTFSLSGIYAPCSISRDIYLEYGDKKAECLYGTIRLPQYGPGCTPG
KIVHCVLDDSLPFCSIVVPSKLFGFMPTQPTMDFCYFEPILDNVVPVLDS
VTFLINEQLYSKLMDLPQEMQQIQFLHYKYNINSMETVVHSRDILTSGLC
QILNCSPFPQGLVDFTETQLILVNDTEQKLSALKYANEDEEYALPKIGTN
SALSIDLESLPCTISRDLLRPAPHINDDNSIYAFTDAETLLRLDVTSGSF
ITVSNMGCVRLVKLFVLLLPNGFKKRTIYAPPKIIASFPDCSVVTISKSN
IGHTDIPIANQVFISRVGGWLQSQKCFQNIILTTLKKFFSESKRILCQND
LIPIAFDSSMADLNIAEENDESDDEDELGQYYKNDSLVWFFVTSAELDCF
SKDNSHFIIDPNRTKLITTNITNRRPLPLSRSNLQRYYGFAETFYYDLHI
FPYVRQLVNILETSFNCSQRGITLNASVLLHSTTNNVGKATMVRFASKYL
GIHLLEIDCLSLTSNSRQLDSTSKIIGYIRAKCENVLPYASPAVIFLAHL
DSILLDVNANQDPEAIKLQKSINFEMSKLLDDFTFKFPGTTFVGSVNNID
NVPSSFRSHMRFEILVPVPSEAQRLRIFQWYLSSHELNRDVQQKVPVSYM
DNISFSSLSSYSAGLTPLDIKSIVETARMTATARFYQESKKCGWLPQSIL
ITQEDLSKATSKARNEFSVSIGAPQIPNVTWDDIGGIDFVKGEILDTIDM
PLKHPELFTSGMKKRSGILFYGPPGTGKTLMAKAIATNFSLNFFSVKGPE
LLNMYIGESEANVRRVFQKAREAKPCVIFFDQIDSVAPKRGNQGDSGGVM
DRIVSQLLAELDGMSTDADGVFVIGATNRPDLLDEALLRPGRFDKLLYLG
IPDTDTKQLNILEALTRKFVLDNDVKLIELAKLCPFNYTGADFYALCSDA
MLNAMSRIARMVEKKVSQHNELTGENISTRRWFDKIATKEDTKVVVKMED
FLKAQEQLTPSVSRAELNHYEAVRANFEGA

3D structure

• PDB: 8c0w Structure of the peroxisomal Pex1/Pex6 ATPase complex bound to a substrate.
• Chain: E
• Resolution: 4.7 Å

Enzymatic activity

• Enzyme Commision number: 3.6.4.-

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	ATP	E	F444 N486 G488 K489 A490 T491 H549 I627 L668	F444 N486 G488 K489 A490 T491 H549 I627 L668
BS02	ATP	E	W731 T776 G777 K778 T779 L780 A941 Y944	W731 T776 G777 K778 T779 L780 A941 Y944

Gene Ontology

Molecular Function

• GO:0005515 protein binding
• GO:0005524 ATP binding
• GO:0016787 hydrolase activity
• GO:0016887 ATP hydrolysis activity
• GO:0140318 protein transporter activity

Biological Process

• GO:0007031 peroxisome organization
• GO:0016558 protein import into peroxisome matrix
• GO:0016562 protein import into peroxisome matrix, receptor recycling
• GO:0043335 protein unfolding

Cellular Component

• GO:0005737 cytoplasm
• GO:0005777 peroxisome
• GO:0005778 peroxisomal membrane
• GO:0005829 cytosol
• GO:0016020 membrane
• GO:1904949 ATPase complex

External links

• PDB: RCSB:8c0w, PDBe:8c0w, PDBj:8c0w
• PDBsum: 8c0w
• PubMed: 37741838
• UniProt: P33760|PEX6_YEAST Peroxisomal ATPase PEX6 (Gene Name=PEX6)