Structure of PDB 8bzl Chain E

Receptor sequence
>8bzlE (length=228) Species: 9606 (Homo sapiens) [Search protein sequence]
NQYDNDVTVWSPQGRIHQIEYAMEAVKQGSATVGLKSKTHAVLVALKRAA
HQKKILHVDNHIGISIAGLTADARLLCNFMRQECLDSRFVFDRPLPVSRL
VSLIGSKTQIPTQRYGRRPYGVGLLIAGYDDMGPHIFQTCPSANYFDCRA
MSIGARSQSARTYLERHMSEFMECNLNELVKHGLRALRETLPAEQDLTTK
NVSIGIVGKDLEFTIYDDDDVSPFLEGL
3D structure
PDB8bzl Peptidic, Blm10-based activators of human 20S proteasome in vitro and in cellulo enhance degradation of proteins connected with neurodegeneration.
ChainE
Resolution2.14 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide E A28 S33 K62 I74 G76 T78 A25 S30 K54 I66 G68 T70
Gene Ontology
Molecular Function
GO:0001530 lipopolysaccharide binding
GO:0005515 protein binding
Biological Process
GO:0002376 immune system process
GO:0002862 negative regulation of inflammatory response to antigenic stimulus
GO:0006511 ubiquitin-dependent protein catabolic process
GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0051603 proteolysis involved in protein catabolic process
Cellular Component
GO:0000502 proteasome complex
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005813 centrosome
GO:0005829 cytosol
GO:0005839 proteasome core complex
GO:0019773 proteasome core complex, alpha-subunit complex
GO:0070062 extracellular exosome

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8bzl, PDBe:8bzl, PDBj:8bzl
PDBsum8bzl
PubMed
UniProtP25786|PSA1_HUMAN Proteasome subunit alpha type-1 (Gene Name=PSMA1)

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