Structure of PDB 8bu5 Chain E

Receptor sequence
>8bu5E (length=331) Species: 9606 (Homo sapiens) [Search protein sequence]
RQTESDWGKRCVDKFDIIGIIGEGTYGQVYKAKDKDTGELVALKKVRLDN
EKEGFPITAIREIKILRQLIHRSVVNMKEIVTDKQDALDFKKDKGAFYLV
FEYMDHDLMGLLESGLVHFSEDHIKSFMKQLMEGLEYCHKKNFLHRDIKC
SNILLNNSGQIKLADFGLARLYNSEESRPYTNKVITLWYRPPELLLGEER
YTPAIDVWSCGCILGELFTKKPIFQANLELAQLELISRLCGSPCPAVWPD
VIRLPYFNTMKPKKQYRRRLREEFSFIPSAALDLLDHMLTLDPSKRCTAE
QTLQSDFLKDVELSKMAPPDLPHWQDCHELW
3D structure
PDB8bu5 Structure of DDB1 bound to DS17-engaged CDK12-cyclin K
ChainE
Resolution3.134 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.11.22: cyclin-dependent kinase.
2.7.11.23: [RNA-polymerase]-subunit kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 RMF E I733 G734 F813 Y815 M816 D817 D819 L866 A876 D877 I21 G22 F101 Y103 M104 D105 D107 L154 A164 D165
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:8bu5, PDBe:8bu5, PDBj:8bu5
PDBsum8bu5
PubMed37679459
UniProtQ9NYV4|CDK12_HUMAN Cyclin-dependent kinase 12 (Gene Name=CDK12)

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