Structure of PDB 8bsu Chain E

Receptor sequence
>8bsuE (length=247) Species: 10116 (Rattus norvegicus) [Search protein sequence]
SLIVTTLLEEPFVMFRKSDRTLYGNDRFEGYCIDLLKELAHILGFSYEIR
LVEDGKYGAQDDKGQWNGMVKELIDHKADLAVAPLTITAVREKAIDFSKP
FMTLGVSILYRKGTPIDSADDLAKQTKIEYGAVKDGATMTFFKKSKISTF
EKMWAFMSSKPSALVKNNEEGIQRTLTADYALLMESTTIEYITQRNCNLT
QIGGLIDSKGYGIGTPMGSPYRDKITIAILQLQEEDKLHIMKEKWWR
3D structure
PDB8bsu Positive allosteric modulation of homomeric kainate receptors GluK1-3
ChainE
Resolution2.9 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#
Ligand Ligand
chain
Binding residues on receptor
(original residue number in PDB)
Binding residues on receptor
(residue number reindexed from 1)
Binding affinity
BS01 2J9 E K105 P106 F107 M108 T109 L236 Q239 K99 P100 F101 M102 T103 L230 Q233
BS02 2J9 E P106 S214 K215 G216 P100 S208 K209 G210
BS03 ZN E D242 H245 D236 H239
BS04 ZN E H245 E249 H239 E243
BS05 KAI E E15 Y63 P90 T92 R97 G142 A143 T144 N174 E191 E9 Y57 P84 T86 R91 G136 A137 T138 N168 E185
Gene Ontology
Molecular Function
GO:0015276 ligand-gated monoatomic ion channel activity
Cellular Component
GO:0016020 membrane

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Molecular Function

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Cellular Component
External links
PDB RCSB:8bsu, PDBe:8bsu, PDBj:8bsu
PDBsum8bsu
PubMed38145505
UniProtP42264|GRIK3_RAT Glutamate receptor ionotropic, kainate 3 (Gene Name=Grik3)

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