Structure of PDB 8bgi Chain E

Receptor sequence
>8bgiE (length=335) Species: 9606 (Homo sapiens) [Search protein sequence]
ITIFTRILDGLLDGYDNRLRPGLGERITQVRTDMYVNSFGPVSDTEMEYT
IDIFFAQTWKDERLRFKGPMQRLPLDNRVADQIWTPDTFFHNDKKSFAHG
MTTPNKMLRIWNDGRVLYTMRLTISAECPMDLEDFPMDEQNCPLKFGSYA
YPNSEVVYVWTNGSTKSVVVAEDGSRLNQYHLMGQTVGTENISTSTGEYT
IMTAHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFGVT
TVLTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFT
KSQPARAAKIDKMSRIVFPILFGTFNLVYWATYLN
3D structure
PDB8bgi The molecular basis of drug selectivity for alpha5 subunit-containing GABA-A receptors
ChainE
Resolution2.56 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 FYP E Y49 F68 T133 Y35 F54 T119
BS02 P9N E I242 Q245 V246 W249 P403 I228 Q231 V232 W235 P319
BS03 FYP E F103 H105 Y163 T208 S209 T210 Y213 F89 H91 Y149 T194 S195 T196 Y199
BS04 P9N E A308 T309 Y312 A294 T295 Y298
Gene Ontology
Molecular Function
GO:0004888 transmembrane signaling receptor activity
GO:0004890 GABA-A receptor activity
GO:0005216 monoatomic ion channel activity
GO:0005230 extracellular ligand-gated monoatomic ion channel activity
Biological Process
GO:0006811 monoatomic ion transport
GO:0034220 monoatomic ion transmembrane transport
Cellular Component
GO:0016020 membrane

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Cellular Component
External links
PDB RCSB:8bgi, PDBe:8bgi, PDBj:8bgi
PDBsum8bgi
PubMed37903907
UniProtP31644|GBRA5_HUMAN Gamma-aminobutyric acid receptor subunit alpha-5 (Gene Name=GABRA5)

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