Structure of PDB 8asc Chain E

Receptor sequence
>8ascE (length=497) Species: 9606 (Homo sapiens) [Search protein sequence]
SGRDSLIFLVDASKAMFESQSEDELTPFDMSIQCIQSVYISKIISSDRDL
LAVVFYGTEKDKNSVNFKNIYVLQELDNPGAKRILELDQFKGQQGQKRFQ
DMMGHGSDYSLSEVLWVCANLFSDVQFKMSHKRIMLFTNEDNPHGNDSAK
ASRARTKAGDLRDTGIFLDLMHLKKPGGFDISLFYRDIISIRVHFEESSK
LEDLLRKVRAKETRKRALSRLKLKLNKDIVISVGIYNLVQKALKPPPIKL
YRETNEPVKTKTRTFNTSTGGLLLPSDTKRSQIYGSRQIILEKEETEELK
RFDDPGLMLMGFKPLVLLKKHHYLRPSLFVYPEESLVIGSSTLFSALLIK
CLEKEVAALCRYTPRRNIPPYFVALVPQEEELDDQKIQVTPPGFQLVFLP
FADDKRKMPFTEKIMATPEQVGKMKAIVEKLRFTYRSDSFENPVLQQHFR
NLEALALDLMEPEQAVDLTLPKVEAMNKRLGSLVDEFKELVYPPDYN
3D structure
PDB8asc PAXX binding to the NHEJ machinery explains functional redundancy with XLF.
ChainE
Resolution2.95 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.6.4.-
4.2.99.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 dna E S33 A255 R258 L281 P285 R403 S1 A217 R220 L243 P247 R365
BS02 peptide E K74 H163 D241 R244 V246 E250 I425 E467 R470 F471 R474 S477 R517 K42 H131 D203 R206 V208 E212 I387 E429 R432 F433 R436 S439 R479
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003678 DNA helicase activity
GO:0003684 damaged DNA binding
GO:0042162 telomeric DNA binding
Biological Process
GO:0000723 telomere maintenance
GO:0006303 double-strand break repair via nonhomologous end joining
Cellular Component
GO:0005634 nucleus
GO:0043564 Ku70:Ku80 complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8asc, PDBe:8asc, PDBj:8asc
PDBsum8asc
PubMed37256950
UniProtP12956|XRCC6_HUMAN X-ray repair cross-complementing protein 6 (Gene Name=XRCC6)

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