Structure of PDB 8arp Chain E

Receptor sequence
>8arpE (length=444) Species: 4932 (Saccharomyces cerevisiae) [Search protein sequence]
NQPQELIKPNWDEELPKLPTFEKNFYVEHESVRDRSDSEIAQFRKENEMT
ISGHDIPKPITTFDEAGFPDYVLNEVKAEGFDKPTGIQCQGWPMALSGRD
MVGIAATGSGKTLSYCLPGIVHINAQPLLAPGDGPIVLVLAPTRELAVQI
QTECSKFGHSSRIRNTCVYGGVPKSQQIRDLSRGSEIVIATPGRLIDMLE
IGKTNLKRVTYLVLDEADRMLDMGFEPQIRKIVDQIRPDRQTLMWSATWP
KEVKQLAADYLNDPIQVQVGSLELSASHNITQIVEVVSDFEKRDRLNKYL
ETASQDNEYKTLIFASTKRMCDDITKYLREDGWPALAIHGDKDQRERDWV
LQEFRNGRSPIMVATDVAARGIDVKGINYVINYDMPGNIEDYVHRIGRTG
RAGATGTAISFFTEQNKGLGAKLISIMREANQNIPPELLKYDRR
3D structure
PDB8arp Nonstructural N- and C-tails of Dbp2 confer the protein full helicase activities.
ChainE
Resolution3.05 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.6.4.13: RNA helicase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ADP E F133 Q140 T159 S161 G162 K163 T164 E205 F81 Q88 T107 S109 G110 K111 T112 E153
Gene Ontology
Molecular Function
GO:0003676 nucleic acid binding
GO:0003723 RNA binding
GO:0003724 RNA helicase activity
GO:0003729 mRNA binding
GO:0004386 helicase activity
GO:0005524 ATP binding
GO:0008186 ATP-dependent activity, acting on RNA
GO:0016787 hydrolase activity
GO:0016887 ATP hydrolysis activity
GO:0030515 snoRNA binding
Biological Process
GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay
GO:0000380 alternative mRNA splicing, via spliceosome
GO:0006364 rRNA processing
GO:0006369 termination of RNA polymerase II transcription
GO:0042254 ribosome biogenesis
GO:0071042 nuclear polyadenylation-dependent mRNA catabolic process
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:1990904 ribonucleoprotein complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8arp, PDBe:8arp, PDBj:8arp
PDBsum8arp
PubMed36894019
UniProtP24783|DBP2_YEAST ATP-dependent RNA helicase DBP2 (Gene Name=DBP2)

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