Structure of PDB 8ar8 Chain E

Receptor sequence
>8ar8E (length=489) Species: 9913 (Bos taurus) [Search protein sequence]
EDDPNFFKMVEGFFDRGASIVEDKLVEDLKTRETEEQKRNRVRGILRIIK
PCNHVLSLSFPIRRDDGSWEVIEGYRAQHSQHRTPCKGGIRYSTDVSVDE
VKALASLMTYKCAVVDVPFGGAKAGVKINPKNYTDNELEKITRRFTMELA
KKGFIGPGVDVPAPDMSTGEREMSWIADTYASTIGHYDINAHACVTGKPI
SQGGIHGRISATGRGVFHGIENFINEASYMSILGMTPGFGDKTFAVQGFG
NVGLHSMRYLHRFGAKCVAVGESDGSIWNPDGIDPKELEDFKLQHGTILG
FPKAKIILEVDCDILIPAASEKQLTKSNAPRVKAKIIAEGANGPTTPEAD
KIFLERNIMVIPDLYLNAGGVTVSYFEWLKNLNHVSYGRLTFKYERDSNY
HLLMSVQESLERKFGKHGGTIPIVPTAEFQDRISGASEKDIVHSGLAYTM
ERSARQIMRTAMKYNLGLDLRTAAYVNAIEKVFRVYNEA
3D structure
PDB8ar8 Structural Basis for the Binding of Allosteric Activators Leucine and ADP to Mammalian Glutamate Dehydrogenase.
ChainE
Resolution2.4 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 1.4.1.3: glutamate dehydrogenase [NAD(P)(+)].
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ADP E I263 H269 K447 S453 R456 I200 H206 K380 S386 R389
BS02 ADP E H145 R146 A176 D179 V180 R519 K548 V552 H82 R83 A113 D116 V117 R452 K481 V485
Gene Ontology
Molecular Function
GO:0000166 nucleotide binding
GO:0004352 glutamate dehydrogenase (NAD+) activity
GO:0004353 glutamate dehydrogenase [NAD(P)+] activity
GO:0016491 oxidoreductase activity
GO:0016639 oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor
Biological Process
GO:0006520 amino acid metabolic process
GO:0006538 glutamate catabolic process
GO:0006541 glutamine metabolic process
GO:0032024 positive regulation of insulin secretion
GO:0072350 tricarboxylic acid metabolic process
Cellular Component
GO:0005739 mitochondrion
GO:0005759 mitochondrial matrix

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8ar8, PDBe:8ar8, PDBj:8ar8
PDBsum8ar8
PubMed36232607
UniProtA0A140T871

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