Structure of PDB 8acg Chain E

Receptor sequence
>8acgE (length=470) Species: 287 (Pseudomonas aeruginosa) [Search protein sequence]
KSPLLVSTPLGLPRCLQASNVVKRLQKLEDIASLNDGNRAAATPGYQASV
DYVKQTLQKAGYKVSVQPFPFTAYYPKGPGSLSATVPQPVTYEWEKDFTY
LSQTEAGDVTAKVVPVDLSLGAGNTSTSGCEAEDFANFPAGSIALIQRGT
CNFEQKAENAAAAGAAGVIIFNQGNTDDRKGLENVTVGESYEGGIPVIFA
TYDNGVAWSQTPDLQLHLVVDVVRKKTETYNVVAETRRGNPNNVVMVGAH
LDSVFEGPGINDNGSGSAAQLEMAVLLAKALPVNKVRFAWWGAAEAGLVG
STHYVQNLAPEEKKKIKAYLNFDMIGSPNFGNFIYDGDGSDFGLQGPPGS
AAIERLFEAYFRLRGQQSEGTEIDFRSDYAEFFNSGIAFGGLFTGAEGLK
TEEQAQKYGGTAGKAYDECYHSKCDGIANINQDALEIHSDAMAFVTSWLS
LSTKVVDDEIAAAGQKLVPR
3D structure
PDB8acg An anti-biofilm cyclic peptide targets a secreted aminopeptidase from P. aeruginosa.
ChainE
Resolution2.84 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.4.11.1: leucyl aminopeptidase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN E D308 E341 H467 D262 E295 H421
BS02 ZN E H296 D308 D369 H250 D262 D323
BS03 ZN E D382 D384 S386 E400 D336 D338 S340 E354
Gene Ontology
Molecular Function
GO:0004177 aminopeptidase activity
GO:0008235 metalloexopeptidase activity
GO:0046872 metal ion binding
Biological Process
GO:0006508 proteolysis
GO:0015628 protein secretion by the type II secretion system
GO:0043952 protein transport by the Sec complex
Cellular Component
GO:0005576 extracellular region

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8acg, PDBe:8acg, PDBj:8acg
PDBsum8acg
PubMed37386135
UniProtQ9HZQ8|LAP_PSEAE Aminopeptidase (Gene Name=lap)

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