Structure of PDB 8a8u Chain E

Receptor sequence
>8a8uE (length=569) Species: 1773 (Mycobacterium tuberculosis) [Search protein sequence]
SLVLDQFGRNLTAAAMEGKLDPVIGREKEIERVMQVLSRRTKNNPVLIGE
PGVGKTAVVEGLAQAIVHGEVPETLKDKQLYTLDLGSLVAGSRYRGDFEE
RLKKVLKEINTRGDIILFIDELHTLVGAIDAASILKPKLARGELQTIGAT
TLDEYRKYIEKDAALERRFQPVQVGEPTVEHTIEILKGLRDRYEAHHRVS
ITDAAMVAAATLADRYINDRFLPDKAIDLIDEAGARMRIRRMVAEVDDEQ
IAEVLGNWTGIPVFKLTEAETTRLLRMEEELHKRIIGQEDAVKAVSKAIR
RTRAGLKDPKRPSGSFIFAGPSGVGKTELSKALANFLFGDDDALIQIDMG
EFHDRFTASRLFGAPPGYVGYEEGGQLTEKVRRKPFSVVLFDEIEKAHQE
IYNSLLQVLEDGRLTDGQGRTVDFKNTVLIFTSNLGTYERMKQKVNDELK
KHFRPEFLNRIDDIIVFHQLTREEIIRMVDLMISRVAGQLKSKDMALVLT
DAAKALLAKRGFDPVLGARPLRRTIQREIEDQLSEKILFEEVGPGQVVTV
DVDNWDGEGPGEDAVFTFT
3D structure
PDB8a8u Structure of the drug target ClpC1 unfoldase in action provides insights on antibiotic mechanism of action.
ChainE
Resolution3.62 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.4.-.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide E Y261 F589 Y601 V602 Y94 F356 Y368 V369
BS02 ADP E P189 V190 I191 G221 K222 T223 A224 D287 I358 L362 P22 V23 I24 G54 K55 T56 A57 D120 I185 L189
BS03 ADP E R517 I519 S555 G556 V557 G558 K559 T560 M730 R771 R284 I286 S322 G323 V324 G325 K326 T327 M478 R519
Gene Ontology
Molecular Function
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016887 ATP hydrolysis activity
GO:0042803 protein homodimerization activity
GO:0044183 protein folding chaperone
Biological Process
GO:0006457 protein folding
Cellular Component
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0009274 peptidoglycan-based cell wall

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8a8u, PDBe:8a8u, PDBj:8a8u
PDBsum8a8u
PubMed36208775
UniProtP9WPC9|CLPC1_MYCTU ATP-dependent Clp protease ATP-binding subunit ClpC1 (Gene Name=clpC1)

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