Structure of PDB 7zpl Chain E

Receptor sequence
>7zplE (length=618) Species: 1318616 (Influenza A virus (A/Zhejiang/DTID-ZJU01/2013(H7N9))) [Search protein sequence]
MDVNPTLLFLKVPVQNAISTTFPYTGDPPYSHGTGTGYTMDTVNRTHKYS
EKGKWTTNTETGAPQLNPIDGPLPEDNEPSGYAQTDCVLEAMAFLEESHP
GIFENSCLETMEIVQQTRVDKLTQGRQTYDWTLNRNQPAATALANTIEVF
RSNGLTANESGRLIDFLKDVMDSMDKEEMEITQRLNKRSYLIRALTLNTM
TKDAERGKLKRRAIATPGMQIRGFVYFVEALARSICEKLEQSGLPVGGNE
KKAKLANVVRKMMTNSQDTELSFTITGDNTKWNENQNPRMFLAMITYITR
NQPEWFRNVLSIAPIMFSNKMARLGKGYMFESKSMKLRTQVPAEMLANID
LKYFNKSTREKIEKIRPLLIDGTASLSPGMMMGMFNMLSTVLGVSILNLG
QKKYTKTTYWWDGLQSSDDFALIVNAPNHEGIQAGVDRFYRTCKLVGINM
SKKKSYINRTGTFEFTSFFYRYGFVANFSMELPSFGVSGINESADMSVGV
TVIKNNMINNDLGPATAQMALQLFIKDYRYTYRCHRGDTQIQTRRAFELK
KLWEQTRSKAGLLVSDGGPNLYNIRNLHIPEVCLKWELMDEDYQGRLCNP
MNPFVSAVATTHSWIPKR
3D structure
PDB7zpl Direct observation of backtracking by influenza A and B polymerases upon consecutive incorporation of the nucleoside analog T1106.
ChainE
Resolution3.12 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.7.48: RNA-directed RNA polymerase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 rna E H32 G33 T34 M356 R365 H32 G33 T34 M329 R338
Gene Ontology
Molecular Function
GO:0000166 nucleotide binding
GO:0003723 RNA binding
GO:0003968 RNA-dependent RNA polymerase activity
GO:0046872 metal ion binding
Biological Process
GO:0001172 RNA-templated transcription
GO:0006351 DNA-templated transcription
GO:0019083 viral transcription
GO:0039523 symbiont-mediated suppression of host mRNA transcription via inhibition of RNA polymerase II activity
GO:0039694 viral RNA genome replication
Cellular Component
GO:0005737 cytoplasm
GO:0030430 host cell cytoplasm
GO:0042025 host cell nucleus

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7zpl, PDBe:7zpl, PDBj:7zpl
PDBsum7zpl
PubMed36596301
UniProtM9TLW3

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