Structure of PDB 7zb5 Chain E

Receptor sequence

>7zb5E (length=1447) Species: 209285 (Thermochaetoides thermophila)

ATRLDRLVTILETGSTRLIRDTAVNQLADWQKQHPEELFNLLSRVVPYLR
HKDWETRTTAAKAIGKIIENAPLYDPNAGRPLLREWPFERLCEFLKVDLF
DPQWETRHGAAMGLREVIRVHGAGAGRRRGKTRKENNDLNRQWLDDLAYR
LLCVLMLDKFTDYSSDTSVAPIRETVGQTLGAVLRHISVESVHAIYRLLY
CMVGMVGLRYVVAVRKDLLLQDGDMIDGVVRCVMQGLGDIDDDVRSVSAA
TLIPMAKEFVMMRRSALDSLINIVWESLSNLGDDLSASTGKIMDLLATLC
SFPEVLEAMKVSASQDEERSFTLLVPRLYPFLRHTITSVRLAVLKALMTF
ANLGGETSQGWLNGRILRLIFQNIIVERDQDTLNMSLELWTTLVRRLAAR
DPAILADEFEAHAEPMMQLALHPIGVPRHPIPMNPALFQKPSGGTYVDGH
MIQGEVDLVGVDVLIRSRISAAKAMGLIMSFIPTPRLASYDTAVLQALSS
PYASTQLAAAMVIDEYAKNCSTPEVASRFIEPLQKIIDLERPSHYRDLVT
YVQRVRSASQQLINLFRDHGKVSQGKLPTLAVVVQGEPEAGPGAFSIANA
EKVVNEDFERLKRLMAPGQRLIALPQLNEAREQTVEVIEEAKAAKEARDA
RIKAAAACALVAMKVLPKKPSPLIKAIMDSIKTEENQELQSRSAATIARL
VQLFTESGRRGPAEKVVANLVKFSCVEVAETPEFPIHAHKTNVILSMQYA
REAKAARITRRGAKEALEILSKNFGAELLERVPTLRTFMEEPLVRAFSGD
LPPEARDPENAFGQEIVDAMSVIRTMTPTLHPALHPFVMQQVPLVIKALR
SDLSVFRYMAAKCMATICSVITVDGMTALVEKVLPSINNPLDLSFRQGAI
EVIYHLIAVMGDAILPYVIFLIVPVLGRMSDSDNQIRLIATTSFATLVKL
VPLEAGIPDPPGLSEELLKGRDRERTFIAQLLDPKKIEPFKIPVAIKAEL
RSYQQEGVNWLAFLNKYHLHGILCDDMGLGKTLQTICIVASDHHQRAEEF
ARTGAPEVRKLPSLIICPPTLSGHWQQEIKTYAPFLTVTAYVGSPAERRA
MKDSLDKTDIVITSYDVCRNDIDVIEKYNWNYCVLDEGHLIKNPKAKITL
AVKRLTSNHRLILTGTPIQNNVLELWSLFDFLMPGFLGAEKVFLDRFAKP
IANSRYSKASSKEQEAGALAIEALHKQVLPFLLRRLKEEVLNDLPPKILQ
NYYCDLSDLQRKLFEDFTKRQHIFQALQYMRKLCNKLGALRDLLVDCGIG
PHRALIFCQMKEMLDMVQNTSVSYLRLDGSVEANKRQDIVNKFNSDPSYD
VLLLTTSVGGLGLNLTGADTVIFVEHDWNPQKDLQAMDRAHRIGQKKVVN
VYRIITRGTLEEKILSLQRFKIDVASTVVNQQNAGLATMDTDQILDL

3D structure

• PDB: 7zb5 Structural basis for TBP displacement from TATA box DNA by the Swi2/Snf2 ATPase Mot1.
• Chain: E
• Resolution: 2.8 Å

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	dna	E	K1439 N1440 A1443 K1444 N1467 I1587 F1588 W1748 K1791	K1142 N1143 A1146 K1147 N1170 I1273 F1274 W1378 K1421
BS02	dna	E	P1392 R1395 S1411 D1413 K1442 F1588 Q1589 M1673 K1674 D1698 R1706 T1725 S1727 G1729	P1095 R1098 S1114 D1116 K1145 F1274 Q1275 M1310 K1311 D1328 R1336 T1355 S1357 G1359

Gene Ontology

Molecular Function

• GO:0003677 DNA binding
• GO:0004386 helicase activity
• GO:0005524 ATP binding
• GO:0016787 hydrolase activity
• GO:0016887 ATP hydrolysis activity
• GO:0017025 TBP-class protein binding
• GO:0140658 ATP-dependent chromatin remodeler activity

Biological Process

• GO:0006338 chromatin remodeling

Cellular Component

• GO:0005634 nucleus

External links

• PDB: RCSB:7zb5, PDBe:7zb5, PDBj:7zb5
• PDBsum: 7zb5
• PubMed: 37106137
• UniProt: G0S6C0