Structure of PDB 7z6s Chain E

Receptor sequence
>7z6sE (length=332) Species: 9606 (Homo sapiens) [Search protein sequence]
LVALRPTNMDRERDKFFQSHYTYNPQFEYQEPMPTAVLEKYCEASGQFIH
QAVGIIEAVLEKFGTYEHFEAATGGQLLTKCQIWSIVRKYMQKEGCAGEV
VVQLSEDLLSQAVMMVENSRPTLAINLTGARQYWLEGMLRHQIGTHYLRG
VNNARQPWHNAEGRLRYGLRPANPTEEGLASLHSVLFRKQPFLWRAALLY
YTIHRAARMSFRQLFQDLERYVQDADVRWEYCVRAKRGQTDTSLPGCFSK
DQVYLDGIVRILRHRQTIDFPLLTSLGKVSYEDVDHLRPHGVLDNTRVPH
FMQDLARYRQQLEHIMATNRLDEAELGRLLPD
3D structure
PDB7z6s Posttranslational modification of microtubules by the MATCAP detyrosinase.
ChainE
Resolution2.9 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.4.17.17: tubulinyl-Tyr carboxypeptidase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN E H280 H285 E316 H141 H146 E177
Gene Ontology
Molecular Function
GO:0004180 carboxypeptidase activity
GO:0004181 metallocarboxypeptidase activity
GO:0005515 protein binding
GO:0008237 metallopeptidase activity
GO:0106423 tubulin-tyrosine carboxypeptidase
Biological Process
GO:0006508 proteolysis
GO:0007420 brain development
Cellular Component
GO:0005737 cytoplasm
GO:0005856 cytoskeleton
GO:0005874 microtubule

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7z6s, PDBe:7z6s, PDBj:7z6s
PDBsum7z6s
PubMed35482892
UniProtQ68EN5|MACA1_HUMAN Microtubule-associated tyrosine carboxypeptidase 1 (Gene Name=MATCAP1)

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