Structure of PDB 7z42 Chain E

Receptor sequence
>7z42E (length=743) Species: 11520 (Influenza B virus) [Search protein sequence]
GMNINPYFLFIDVPIQAAISTTFPYTGVPPYSHGTGTGYTIDTVIRTHEY
SNKGKQYISDVTGCTMVDPTNGPLPEDNEPSAYAQLDCVLEALDRMDEEH
PGLFQAASQNAMETLMVTTVDKLTQGRQTFDWTVCRNQPAATALNTTITS
FRLNDLNGADKGGLIPFCQDIIDSLDRPEMTFFSVKNIKKKIKRIPMKVK
DKITKVEYIKRALSLNTMTKDAERGKLKRRAIATAGIQIRGFVLVVENLA
KNICENLEQSGLPVGGNEKKAKLSNAVAKMLSNCPPGGISMTVTGDNTKW
NECLNPRIFLAMTERITRDSPIWFRDFCSIAPVLFSNKIARLGKGFMITS
KTKRLKAQIPCPDLFSIPLERYNEETRAKLKKLKPFFNEEGTASLSPGMM
MGMFNMLSTVLGVAALGIKNIGNKEYLWDGLQSSDDFALFVNAKDEETCM
EGINDFYRTCKLLGINMSKKKSYCNETGMFEFTSMFYRDGFVSNFAMELP
SFGVAGVNESADMAIGMTIIKNNMINNGMGPATAQTAIQLFIADYRYTYK
CHRGDSKVEGKRMKIIKELWENTKGRDGLLVADGGPNIYNLRNLHIPEIV
LKYNLMDPEYKGRLLHPQNPFVGHLSIEGIKEADITPAHGPVKKMDYDAV
SGTHSWRTKRNILNTDQRNMILEEQCYAKCCNLFEACFNSASYRKPVGQH
SMLEAMAHRLRMDARLDYESGRMSKDDFEKAMAHLGEIGYIGS
3D structure
PDB7z42 Type B and type A influenza polymerases have evolved distinct binding interfaces to recruit the RNA polymerase II CTD.
ChainE
Resolution2.418 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.7.48: RNA-directed RNA polymerase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 rna E H32 G33 T34 Y38 K365 L674 H33 G34 T35 Y39 K356 L663
Gene Ontology
Molecular Function
GO:0000166 nucleotide binding
GO:0003723 RNA binding
GO:0003968 RNA-dependent RNA polymerase activity
GO:0034062 5'-3' RNA polymerase activity
GO:0046872 metal ion binding
Biological Process
GO:0001172 RNA-templated transcription
GO:0006351 DNA-templated transcription
GO:0019083 viral transcription
GO:0039523 symbiont-mediated suppression of host mRNA transcription via inhibition of RNA polymerase II activity
GO:0039694 viral RNA genome replication
Cellular Component
GO:0030430 host cell cytoplasm
GO:0042025 host cell nucleus

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7z42, PDBe:7z42, PDBj:7z42
PDBsum7z42
PubMed35605026
UniProtQ5V8Y6

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