Structure of PDB 7yxo Chain E

Receptor sequence
>7yxoE (length=230) Species: 32644 (unidentified) [Search protein sequence]
PTLISLLEVIEPEVLYSGYDSTSTRLMSTLNRLGGRQVVSAVKWAKALPG
FRNLHLDDQMTLLQYSWMSLMAFSLGWRSYKQSNGNMLCFAPDLVINEER
MQLPYMYDQCQQMLKISSEFVRLQVSYDEYLCMKVLLLLSTVPKDGLQAV
FDEIRMTYIKELGKAIVKWQRFYQLTKLLDSMHEMVGGLLQFCFYTFVNK
SLSVEFPEMLAEIISNQLPKFKAGSVKPLL
3D structure
PDB7yxo The multivalency of the glucocorticoid receptor ligand-binding domain explains its manifold physiological activities.
ChainE
Resolution2.99 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide E M752 E755 N759 M209 E212 N216
BS02 DEX E M560 L563 Q570 M601 M604 A605 F623 T739 M27 L30 Q37 M68 M71 A72 F90 T196
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0004879 nuclear receptor activity
GO:0034056 estrogen response element binding
Biological Process
GO:0006357 regulation of transcription by RNA polymerase II
GO:0030518 nuclear receptor-mediated steroid hormone signaling pathway

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Molecular Function
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Biological Process
External links
PDB RCSB:7yxo, PDBe:7yxo, PDBj:7yxo
PDBsum7yxo
PubMed36464162
UniProtA0A1X8XLE9

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