Structure of PDB 7ysu Chain E

Receptor sequence
>7ysuE (length=210) Species: 9606 (Homo sapiens) [Search protein sequence]
TGAPYWTRPERMDKKLLAVPAANTVRFRCPAAGNPTPSISWLKNGREFRG
EHRIGGIKLRHQQWSLVMESVVPSDRGNYTCVVENKFGSIRQTYTLDVLE
RSPHRPILQAGLPANQTAVLGSDVEFHCKVYSDAQPHIQWLKHVEVNGSK
VGPDGTPYVTVLKTAGANTTDKELEVLSLHNVTFEDAGEYTCLAGNSIGF
SHHSAWLVVL
3D structure
PDB7ysu Structural basis for FGF hormone signalling.
ChainE
Resolution3.2 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.10.1: receptor protein-tyrosine kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 SGN E R209 Q211 R60 Q62
BS02 SGN E R209 Q212 S214 R60 Q63 S65
BS03 IDS E R175 R177 R26 R28
BS04 SGN E R160 R177 Q212 R11 R28 Q63
BS05 CU E H253 D282 H104 D133
External links
PDB RCSB:7ysu, PDBe:7ysu, PDBj:7ysu
PDBsum7ysu
PubMed37286607
UniProtP22607|FGFR3_HUMAN Fibroblast growth factor receptor 3 (Gene Name=FGFR3)

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