Structure of PDB 7yo0 Chain E

Receptor sequence

>7yo0E (length=882) Species: 9606 (Homo sapiens)

PCDSRGQRMWWAFLASSMVTFFGGLFIILLWRTLKYLWEVGWMTSVKDWA
GVMISAQTLTGRVLVVLVFALSIGALVIYFIDSSNPIESCQNFYKDFTLQ
IDMAFNVFFLLYFGLRFIAANDKLWFWLEVNSVVDFFTVPPVFVSVYLNR
SWLGLRFLRALRLIQFSEILQFLNILKTSNSIKLVNLLSIFISTWLTAAG
FIHLVENSGDPWENFQNNQALTYWECVYLLMVTMSTVGYGDVYAKTTLGR
LFMVFFILGGLAMFASYVPEIIELIGNRKKYGGSYSAVSGRKHIVVCGHI
TLESVSNFLKDFLHKDRDDVNVEIVFLHNISPNLELEALFKRHFTQVEFY
QGSVLNPHDLARVKIESADACLILANKYCADPDAEDASNIMRVISIKNYH
PKIRIITQMLQYHNKAHLLNIPSWNWKEGDDAICLAELKLGFIAQSCLAQ
GLSTMLANLFSMRSFIKIEEDTWQKYYLEGVSNEMYTEYLSSAFVGLSFP
TVCELCFVKLKLLMISRILINPGNGTLGFFIASDAKEVKRAFFYCKKKYD
STGMFHWCAPKEIEKVILTRSEAAMTVLSGHVVVCIFGDVSSALIGLRNL
VMPLRASNFHYHELKHIVFVGSIEYLKREWETLHNFPKVSILPGTPLSRA
DLRAVNINLCDMCVILSANQNNIDDTSLQDKECILASLNIKSMQFDTTGV
NIPIITELVNDTNVQFLDQDDDDDPDTELYLTQPFACGTAFAVSVLDSLM
SATYFNDNILTLIRTLVTGGATPELEALIAEENALRGGYSTPQTLANRDR
CRVAQLALLDGPFADLGDGGCYGDLFCKALKTYNMLCFGIYRLRDAHLST
PSQCTKRYVITNPPYEFELVPTDLIFCLMQFD

3D structure

• PDB: 7yo0 Structural basis for dual allosteric gating modulation of Slo1-LRRC channel complex
• Chain: E
• Resolution: 3.6 Å

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	PGW	E	I39 W43 R44 N172 K174 W178	I27 W31 R32 N121 K123 W127
BS02	CA	E	D367 R514 S533 E535 S600	D316 R463 S482 E484 S533
BS03	CA	E	Q889 D892 D895 D897	Q715 D718 D721 D723

Gene Ontology

Molecular Function

• GO:0005216 monoatomic ion channel activity

Biological Process

• GO:0006811 monoatomic ion transport
• GO:0006813 potassium ion transport
• GO:0055085 transmembrane transport

Cellular Component

• GO:0016020 membrane

External links

• PDB: RCSB:7yo0, PDBe:7yo0, PDBj:7yo0
• PDBsum: 7yo0
• UniProt: Q12791|KCMA1_HUMAN Calcium-activated potassium channel subunit alpha-1 (Gene Name=KCNMA1)