Structure of PDB 7yk1 Chain E

Receptor sequence
>7yk1E (length=306) Species: 9606 (Homo sapiens) [Search protein sequence]
PNIVLFSGSSHQDLSQRVADRLGLELGKVVTKKFSNQETSVEIGESVRGE
DVYIIQSGCGEINDNLMELLIMINACKIASSSRVTAVIPCFPYARQDKKD
KSRAPISAKLVANMLSVAGADHIITMDLHASQIQGFFDIPVDNLYAEPAV
LQWIRENIAEWKNCIIVSPDAGGAKRVTSIADRLNVEFALIHKEMVLVGD
VKDRVAILVDDMADTCGTICHAADKLLSAGATKVYAILTHGIFSGPAISR
INNAAFEAVVVTNTIPQEDKMKHCTKIQVIDISMILAEAIRRTHNGESVS
YLFSHV
3D structure
PDB7yk1 Structural basis of human PRPS2 filaments.
ChainE
Resolution3.08 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.6.1: ribose-phosphate diphosphokinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ADP E K100 D101 K102 S103 R104 K99 D100 K101 S102 R103
BS02 ADP E R96 Q97 H130 R95 Q96 H129
BS03 ADP E F35 N37 E39 F34 N36 E38
BS04 PO4 E D224 C226 D214 C216
BS05 ADP E S308 S310 F313 S298 S300 F303
Gene Ontology
Molecular Function
GO:0000287 magnesium ion binding
GO:0004749 ribose phosphate diphosphokinase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016301 kinase activity
GO:0042802 identical protein binding
GO:0042803 protein homodimerization activity
GO:0046872 metal ion binding
Biological Process
GO:0006015 5-phosphoribose 1-diphosphate biosynthetic process
GO:0006098 pentose-phosphate shunt
GO:0006139 nucleobase-containing compound metabolic process
GO:0006164 purine nucleotide biosynthetic process
GO:0009156 ribonucleoside monophosphate biosynthetic process
GO:0009165 nucleotide biosynthetic process
GO:0016310 phosphorylation
GO:0044249 cellular biosynthetic process
Cellular Component
GO:0002189 ribose phosphate diphosphokinase complex
GO:0005737 cytoplasm
GO:0005829 cytosol

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7yk1, PDBe:7yk1, PDBj:7yk1
PDBsum7yk1
PubMed37248548
UniProtP11908|PRPS2_HUMAN Ribose-phosphate pyrophosphokinase 2 (Gene Name=PRPS2)

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