Structure of PDB 7yh9 Chain E

Receptor sequence
>7yh9E (length=219) Species: 287 (Pseudomonas aeruginosa) [Search protein sequence]
SLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFT
AKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELT
NELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERK
ILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGD
ASLLKLTLEQAVKGLNESK
3D structure
PDB7yh9 Metal binding pharmacophore click-derived discovery of new broad-spectrum metallo-beta-lactamase inhibitors.
ChainE
Resolution2.39 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.5.2.6: beta-lactamase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN E D99 C176 H215 D79 C156 H195
BS02 ZN E H95 H97 H157 H75 H77 H137
BS03 IT0 E V43 V49 H97 D99 H157 C176 K179 G184 N185 H215 V23 V29 H77 D79 H137 C156 K159 G164 N165 H195
Gene Ontology
Molecular Function
GO:0008270 zinc ion binding
GO:0008800 beta-lactamase activity
GO:0016787 hydrolase activity
GO:0046872 metal ion binding
Biological Process
GO:0017001 antibiotic catabolic process
GO:0046677 response to antibiotic
Cellular Component
GO:0042597 periplasmic space

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Cellular Component
External links
PDB RCSB:7yh9, PDBe:7yh9, PDBj:7yh9
PDBsum7yh9
PubMed37209449
UniProtQ79MP6

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