Structure of PDB 7yed Chain E

Receptor sequence
>7yedE (length=1058) Species: 538123 (Mammalian orthoreovirus 3) [Search protein sequence]
SSEIQRHITEFISSWQNHPIVQVSADVENRKTAQLLHADTPRLVTWDAGL
CTSFKIVPIVPAQVPQDVLAYTFFTSSYAIQSPFPEAAVSRIVVHTRWAS
NVDFDRDSSVIMAPPTENNIHLFKQLLNTETLSVRGANPLMFRANVLHML
LEFVLDNLYLNRHTGFSQDHTPFTEGANLRSLPGPDAEKWYSIMYPTRMG
TPNVSKICNFVASCVRNRVGRFDRAQMMNGAMSEWVDVFETSDALTVSIR
GRWMARLARMNINPTEIEWALTECAQGYVTVTSPYAPSVNRLMPYRISNA
ERQISQIIRVMNIGNNATVIQPVLQDISVLLQRISPLQIDPTIISNTMST
VSELSPASSILGKLRPSNSDFSSFRVALAGWLYNGVVTTVIDDSSYPKDG
GSVTSLENLWDFFILALALPLTTDPCAPVKAFMTLANMMVGFETIPMDNQ
IYTQSRRASAFSTPHTWPRCFMNIQLISPIDAPILRQWAEIIHRYWPNPS
QIRYGTPNVFGSANLFTPPEVLLLPIDHQPANVTTPTLDFTNELTNWRAR
VCELMKNLVDNQRYQPGWTQSLVSSMRGTLGKLKLIKSMTPMYLQQLAPV
ELAVIAPMLPFPPFQVPYVRLDRDRVPTMVGVTRQSRDTITQPALSLSTT
NTTVGVPLALDARAITVALLSGKYPPDLVTNVWYADAIYPMYADTEVFSN
LQRDVITCEAVQTLVTLVAQISETQYPVDRYLDWIPSLRASAATAATFAE
WVNTSMKTAFDLSDMLLEPLLSGDPRMTQLAIQYQQYNGRTFNVIPEMPG
SVIADCVQLTAEVFNHEYNLFGIARGDIIIGRVQSTHLWSPLAPPPDLVF
DRDTPGVHIFGRDCRISFGMNGAAPMIRDETGMMVPFEGNWIFPLALWQM
NTRYFNQQFDAWIKTGELRIRIEMGAYPYMLHYYDPRQYANAWNLTSAWL
EEITPTSIPSVPFMVPISSDHDISSAPAVQYIISTEYNDRSLFCTNSSSP
QTIAGPDKHIPVERYNILTNPDAPPTQIQLPEVVDLYNVVTRYAYETPPI
TAVVMGVP
3D structure
PDB7yed In situ structures of polymerase complex of mammalian reovirus illuminate RdRp activation and transcription regulation.
ChainE
Resolution3.0 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.6.4.13: RNA helicase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 rna E L571 K580 T786 S788 L354 K363 T569 S571
Gene Ontology
Molecular Function
GO:0003724 RNA helicase activity
GO:0004386 helicase activity
GO:0016787 hydrolase activity
Biological Process
GO:0006370 7-methylguanosine mRNA capping
Cellular Component
GO:0019028 viral capsid
GO:0039625 viral inner capsid

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7yed, PDBe:7yed, PDBj:7yed
PDBsum7yed
PubMed36469786
UniProtC9E874

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