Structure of PDB 7xxr Chain E

Receptor sequence

>7xxrE (length=482) Species: 285500 (Streptomyces luteocolor) [Search protein sequence]

QTDVIVVGNGVLGLSVGVEIARTRPDVRVTLLGKPARQYGATPAAGAMLG
AFGEVTAHALASEHGRKKHALAVQAQRLWPEWIESLEATGTAADGRIKTA
DDTVVLLNTVGHSALDDANFAAVLTALKEANAPHEEIAVESVDWIDPDPN
SRPLRALHIEGEGSVDSGILLAALERSFLQAGGRLHPVDATEIRASHGRV
EGVVTDDGDFLPAGHVVVAAGARSQRLVAALPGLAHRIPRIYDGVGVSAL
VDTWDGSGPATVLRTSNRAFACGLHLVPRAGGSVYIGATNAVCLEPRGAA
SIEETVFLFNCATHQLHRGLNGSELRKVQVGSAPAPIDGFPLIGGTSVEG
LWMLSGTYRDGLHMSPLLARHVVSLMDGGTGVDGLREFRPERDLISAWSR
EEILDDVVRHTMATGYEFPWRLPLEWPHMMETFLQGPFAELADRLSDTYT
PPADLMTAIMFSEREQQDELIAYYADVHREWH

3D structure

PDB

7xxr N-Formimidoylation/-iminoacetylation modification in aminoglycosides requires FAD-dependent and ligand-protein NOS bridge dual chemistry.

Chain

Resolution

2.4 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	FAD	E	V16 G17 N18 G19 L21 G42 R46 Q47 A50 T51 A54 A56 M57 D198 A199 A229 G230 R232 T366 Y367 R368 D369 G370 L371 H372	V7 G8 N9 G10 L12 G33 R37 Q38 A41 T42 A45 A47 M48 D189 A190 A220 G221 R223 T357 Y358 R359 D360 G361 L362 H363
BS02	I55	E	N299 S310 E312 T423 T466 F470	N290 S301 E303 T414 T457 F461

Gene Ontology

	Molecular Function
GO:0000166	nucleotide binding
GO:0016491	oxidoreductase activity

	Cellular Component
GO:0005737	cytoplasm

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Molecular Function

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Cellular Component

External links

PDB	RCSB:7xxr, PDBe:7xxr, PDBj:7xxr
PDBsum	7xxr
PubMed	37137912
UniProt	A0A125SZC1

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