Structure of PDB 7wm4 Chain E

Receptor sequence
>7wm4E (length=661) Species: 10090 (Mus musculus) [Search protein sequence]
CTVRYNVADCSHLKLTHIPDDLPSNITVLNLTHNQLRRLPPTNFTRYSQL
AILDAGFNSISKLEPELCQILPLLKVLNLQHNELSQISDQTFVFCTNLTE
LDLMSNSIHKIKSNPFKNQKNLIKLDLSHNGLSSTKLGTGVQLENLQELL
LAKNKILALRSEELEFLGNSSLRKLDLSSNPLKEFSPGCFQTIGKLFALL
LNNAQLNPHLTEKLCWELSNTSIQNLSLANNQLLATSESTFSGLKWTNLT
QLDLSYNNLHDVGNGSFSYLPSLRYLSLEYNNIQRLSPRSFYGLSNLRYL
SLKRAFTKSHPNIDDFSFQWLKYLEYLNMDDNNIPSTKSNTFTGLVSLKY
LSLSKTFTSLQTLTNETFVSLAHSPLLTLNLTKNHISKIANGTFSWLGQL
RILDLGLNEIEQKLSGQEWRGLRNIFEIYLSYNKYLQLSTSSFALVPSLQ
RLMLRRVALKNVDISPSPFRPLRNLTILDLSNNNIANINEDLLEGLENLE
ILDFQHNNLARLWNPGGPVNFLKGLSHLHILNLESNGLDEIPVGVFKNLF
ELKSINLGLNNLNKLEPFIFDDQTSLRSLNLQKNLITSVEKDVFGPPFQN
LNSLDMRFNPFDCTCESISWFVNWINQTHTNISELSTHYLCNTPHHYYGF
PLKLFDTSSCK
3D structure
PDB7wm4 TLR3 forms a laterally aligned multimeric complex along double-stranded RNA for efficient signal transduction.
ChainE
Resolution3.2 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 rna E S113 N516 N518 H540 N542 S85 N482 N484 H506 N508
BS02 rna E Q63 F85 H109 R545 K620 Q35 F57 H81 R511 K583
External links
PDB RCSB:7wm4, PDBe:7wm4, PDBj:7wm4
PDBsum7wm4
PubMed36631495
UniProtQ99MB1|TLR3_MOUSE Toll-like receptor 3 (Gene Name=Tlr3)

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