Structure of PDB 7wlu Chain E

Receptor sequence
>7wluE (length=1498) Species: 10090 (Mus musculus) [Search protein sequence]
ELVTGIYVKYWIYVCAGMFIVVSFAGRLVVYKIVYMFLFLLCLTLFQVYY
TLWRKLLRVFWWLVVAYTMLVLIAVYTFQFQDFPTYWRNLTGFTDEQLGD
LGLEQFSVSELFSSILIPGFFLLACILQLHYFHRPFMQLTDLELDLAASF
SAVLTRIQVFVRRLLELHVFKLVALYTVWVALKEVSVMNLLLVVLWAFAL
PYPRFRPMASCLSTVWTCIIIVCKMLYQLKIVNPFGVRKGYPNLGYIQNH
LQILLLLVFEAVVYRRQEHYRRQHGTRQRLDQDLLSCLKYFINFFFYKFG
LEICFLMAVNVIGQRMNFMVILHGCWLVAILTRRRREAIARLWPNYCLFL
TLFLLYQYLLCLGMPPALCIDYPWRWSKAIPMNSALIKWLYLPDFFRAPN
STNLISDFLLLLCASQQWQVFSAERTEEWQRMAGEPNPIPNFIHCRSYLD
MLKVAVFRYLFWLVLVVVFVAGATRISIFGLGYLLACFYLLLFGTTLLQK
DTRAQLVLWDCLILYNVTVIISKNMLSLLSCVFVEQMQSNFCWVIQLFSL
VCTVEAGIIWDSICFFFLLLQRRIFLSHYFLHVSADLKATALQASRGFAL
YNAANLKSINFHRQIEEKSLAQLKRQMKRIRAKQEKYRQSQALDHATVIH
SGDYFLFESDAFQMAYQAWVTNAQTVLRQRRERARQERAEQLGRSHMMQR
VLSTMQFLWVLGQATVDGLTRWLRAFTKHHRTMSDVLCAERYLLTQELLR
VGEVRRGVLDQLASELLLDRRLHIPELEEAERFEAQQGRTLRLLRAGYQC
VAAHSELLCYFIIILNHMVTASAASLVLPVLVFLWAMLTIPRPSKRFWMT
AIVFTEVMVVTKYLFQFPPRILGLEKTDSYIKYDLVQLMALFFHRSQLLC
YGLWDRRLQSFCVSLAQSFYQPLQRFFHDILHTKYRAATDVYALMFLADI
VDIIIIIFGFWAFGKHSAATDIASSLSDDQVPQAFLFMLLVQFGTMVIDR
ALYLRKTVLGKLAFQVVLVVAIHIWMFFILPAVTERMFSQNAVAQLWYFV
KCIYFALSAYQIRCGYPTRILGNFLTKKYNHLNLFLFQGFRLVPFLVELR
AVMDWVWTDTTLSLSNWMCVEDIYANIFIIKCSRETEKKYPQPKGQKKKK
IVKYGMGGLIILFLIAIIWFPLLFMSLIRVVGVVNQPIDVTVTLKLGGYE
PLFTMSAQQPSIVPFTPQAYEELSQQFDPYPLAMQFISQYSPEDIVTAQI
EGSSGALWRISPPSRAQMKQELYNGTADITLRFTWNFQRDLAKGGTVEYT
NEKHTLELAPNSTARRQLAQLLEGRPDQSVVIPHLFPKYIRAPNGPEANP
VKQLQPDEEEDYLGVRIQLRREQVGGTKASDFLEWWVIELQDCKADCNLL
PMVIFSDKVSPPAGYGIVGLYVSIVLVVGKFVRGFFSEISHSIMFEELPC
VDRILKLCQDIFLVRETRELELEEELYAKLIFLYRSPETMIKWTRERE
3D structure
PDB7wlu Structure deformation and curvature sensing of PIEZO1 in lipid membranes.
ChainE
Resolution6.81 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 PLX E W1445 Q2177 F2198 W669 Q1142 F1163
Gene Ontology
Molecular Function
GO:0005261 monoatomic cation channel activity
GO:0005515 protein binding
GO:0008381 mechanosensitive monoatomic ion channel activity
GO:0042802 identical protein binding
GO:0140135 mechanosensitive monoatomic cation channel activity
Biological Process
GO:0006812 monoatomic cation transport
GO:0010831 positive regulation of myotube differentiation
GO:0033625 positive regulation of integrin activation
GO:0033634 positive regulation of cell-cell adhesion mediated by integrin
GO:0034220 monoatomic ion transmembrane transport
GO:0042391 regulation of membrane potential
GO:0050982 detection of mechanical stimulus
GO:0098655 monoatomic cation transmembrane transport
Cellular Component
GO:0005783 endoplasmic reticulum
GO:0005789 endoplasmic reticulum membrane
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0031258 lamellipodium membrane
GO:0032420 stereocilium
GO:0032437 cuticular plate
GO:0033116 endoplasmic reticulum-Golgi intermediate compartment membrane
GO:0042995 cell projection

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7wlu, PDBe:7wlu, PDBj:7wlu
PDBsum7wlu
PubMed35388220
UniProtE2JF22|PIEZ1_MOUSE Piezo-type mechanosensitive ion channel component 1 (Gene Name=Piezo1)

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