Structure of PDB 7wl0 Chain E

Receptor sequence
>7wl0E (length=216) Species: 9606 (Homo sapiens) [Search protein sequence]
QKEEEARKVKSGIRQMRLFSQDECAKIEARIDEVVSRAEKGLYNEHTVDR
APLRNKYFFGEGYTYGAQLQKRGPGQERLYPPGDVDEIPEWVHQLVIQKL
VEHRVIPEGFVNSAVINDYQPGGCIVSHVDPIHIFERPIVSVSFFSDSAL
CFGCKFQFKPIRVSEPVLSLPVRRGSVTVLSGYAADEITHCIRPQDIKER
RAVIILRKTRLDAPRL
3D structure
PDB7wl0 Mechanisms of substrate recognition and N6-methyladenosine demethylation revealed by crystal structures of ALKBH5-RNA complexes.
ChainE
Resolution2.5 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 1.14.11.53: mRNA N(6)-methyladenine demethylase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 rna E P128 L129 R130 Y139 Y141 G142 G149 P150 E153 I201 V202 S203 H204 V205 F234 I237 T265 P52 L53 R54 Y63 Y65 G66 G73 P74 E77 I125 V126 S127 H128 V129 F158 I161 T189
BS02 MN E H204 D206 H266 H128 D130 H190
Gene Ontology
Molecular Function
GO:0035515 oxidative RNA demethylase activity
Biological Process
GO:0006397 mRNA processing

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Molecular Function
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Biological Process
External links
PDB RCSB:7wl0, PDBe:7wl0, PDBj:7wl0
PDBsum7wl0
PubMed35333330
UniProtQ6P6C2|ALKB5_HUMAN RNA demethylase ALKBH5 (Gene Name=ALKBH5)

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