Structure of PDB 7wbb Chain E

Receptor sequence
>7wbbE (length=726) Species: 4932 (Saccharomyces cerevisiae) [Search protein sequence]
KLPAEFITRPHPSKDHGKETCTAYIHPNVLSSLEINPGSFCTVGKIGENG
ILVIARAGDEEVHPVNVITLSTTIRSVGNLILGDRLELKKAQVQPPYATK
VTVGSLQGYNILECMEEKVIQKLLDDSGVIMPGMIFQNLKTKAGDESIDV
VITDASDFYLSPPFIFRKGSTHITFSKETQANRKYNLPEPLSYAAVGGLD
KEIESLKSAIEIPLHQPTLFSSFGVSPPRGILLHGPPGTGKTMLLRVVAN
TSNAHVLTINGPSIVSKYLGETEAALRDIFNEARKYQPSIIFIDQIDSIA
PNRANDDSGEVESRVVATLLTLMDGMGAAGKVVVIAATNRPNSVDPALRR
PGRFDQEVEIGIPDVDARFDILTKQFSRMSSDRHVLDSEAIKYIASKTHG
YVGADLTALCRESVMKTIQRGLGTDANIDKFSLKVTLKDVESAMVDIRPS
AMREIFLEMPKVYWSDIGGQEELKTKMKEMIQLPLEASETFARLGISAPK
GVLLYGPPGCSKTLTAKALATESGINFLAVKGPEIFNKYVGESERAIREI
FRKARSAAPSIIFFDQIDALSPDRDGSSTSAANHVLTSLLNEIDGVEELK
GVVIVAATNRPDEIDAALLRPGRLDRHIYVGPPDVNARLEILKKCTKKFN
TEESGVDLHELADRTEGYSGAEVVLLCQEAGLAAIMEDLDVAKVELRHFE
KAFKGIARGITPEMLSYYEEFALRSG
3D structure
PDB7wbb Structural dynamics of AAA + ATPase Drg1 and mechanism of benzo-diazaborine inhibition.
ChainE
Resolution3.6 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.6.4.10: non-chaperonin molecular chaperone ATPase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide E K318 L320 K267 L269
BS02 ATP E R401 R404 R350 R353
BS03 ATP E R671 R674 R620 R623
BS04 ATP E A246 G289 T290 G291 K292 T293 G454 A455 A195 G238 T239 G240 K241 T242 G403 A404
BS05 ATP E G519 S562 K563 T564 L565 A722 G468 S511 K512 T513 L514 A671
Gene Ontology
Molecular Function
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016787 hydrolase activity
GO:0016887 ATP hydrolysis activity
Biological Process
GO:0009410 response to xenobiotic stimulus
GO:0034214 protein hexamerization
GO:0042254 ribosome biogenesis
GO:0042273 ribosomal large subunit biogenesis
Cellular Component
GO:0005737 cytoplasm
GO:0030687 preribosome, large subunit precursor

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7wbb, PDBe:7wbb, PDBj:7wbb
PDBsum7wbb
PubMed36351914
UniProtP32794|AFG2_YEAST ATPase family gene 2 protein (Gene Name=AFG2)

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