Structure of PDB 7w6l Chain E

Receptor sequence

>7w6lE (length=151) Species: 9606 (Homo sapiens) [Search protein sequence]

LGSKSSQYRKMKTEWKSNVYLARSRIQGLGLYAARDIEKHTMVIEYIGTI
IRNEVANRKEKLYESQNRGVYMFRMDNDHVIDATLTGGPARYINHSCAPN
CVAEVVTFERGHKIIISSSRRIQKGEELCYDYKFDKIPCHCGAVNCRKWM
N

3D structure

PDB

7w6l Structural basis for product specificities of MLL family methyltransferases.

Chain

Resolution

2.26 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

2.1.1.364: [histone H3]-lysine(4) N-methyltransferase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)
BS01	peptide	E	Y4762 K4766 W4769 E4799 I4801 G4802 T4803 I4804 R4806 V4809 R4812 K4813 K4867	Y8 K12 W15 E45 I47 G48 T49 I50 R52 V55 R58 K59 K113
BS02	ZN	E	C4851 C4899 C4901 C4906	C97 C139 C141 C146
BS03	SAH	E	I4780 Q4781 G4782 L4783 Y4825 R4845 Y4846 N4848 H4849 Y4886 C4899 H4900 M4910	I26 Q27 G28 L29 Y71 R91 Y92 N94 H95 Y132 C139 H140 M150

External links

PDB	RCSB:7w6l, PDBe:7w6l, PDBj:7w6l
PDBsum	7w6l
PubMed	36108631
UniProt	Q8NEZ4\|KMT2C_HUMAN Histone-lysine N-methyltransferase 2C (Gene Name=KMT2C)

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