Structure of PDB 7w39 Chain E

Receptor sequence
>7w39E (length=389) Species: 9606 (Homo sapiens) [Search protein sequence]
MADPRDKALQDYRKKLLEHKEIDGRLKELREQLKELTKQYEKSENDLKAL
QSVGQIVGEVLKQLTEEKFIVKATNGPRYVVGCRRQLDKSKLKPGTRVAL
DMTTLTIMRYLPREVDPLVYNMSHEDPGNVSYSEIGGLSEQIRELREVIE
LPLTNPELFQRVGIIPPKGCLLYGPPGTGKTLLARAVASQLDCNFLKVVS
SSIVDKYIGESARLIREMFNYARDHQPCIIFMDEIDAIGGRRFSEGTSAD
REIQRTLMELLNQMDGFDTLHRVKMIMATNRPDTLDPALLRPGRLDRKIH
IDLPNEQARLDILKIHAGPITKHGEIDYEAIVKLSDGFNGADLRNVCTEA
GMFAIRADHDFVVQEDFMKAVRKVADSKKLESKLDYKPV
3D structure
PDB7w39 USP14-regulated allostery of the human proteasome by time-resolved cryo-EM.
ChainE
Resolution3.2 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ATP E R291 R294 R291 R294
BS02 ATP E I135 P176 G177 T178 G179 K180 T181 L182 N280 I312 H316 G340 A341 I135 P176 G177 T178 G179 K180 T181 L182 N280 I312 H316 G340 A341
Gene Ontology
Molecular Function
GO:0005524 ATP binding
GO:0016887 ATP hydrolysis activity
Cellular Component
GO:0000502 proteasome complex

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Molecular Function
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Cellular Component
External links
PDB RCSB:7w39, PDBe:7w39, PDBj:7w39
PDBsum7w39
PubMed35477760
UniProtA0A087X2I1

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