Structure of PDB 7w38 Chain E

Receptor sequence
>7w38E (length=375) Species: 9606 (Homo sapiens) [Search protein sequence]
KLLEHKEIDGRLKELREQLKELTKQYEKSENDLKALQSVGQIVGEVLKQL
TEEKFIVKATNGPRYVVGCRRQLDKSKLKPGTRVALDMTTLTIMRYLPRE
VDPLVYNMSHEDPGNVSYSEIGGLSEQIRELREVIELPLTNPELFQRVGI
IPPKGCLLYGPPGTGKTLLARAVASQLDCNFLKVVSSSIVDKYIGESARL
IREMFNYARDHQPCIIFMDEIDAIGGRRFSEGTSADREIQRTLMELLNQM
DGFDTLHRVKMIMATNRPDTLDPALLRPGRLDRKIHIDLPNEQARLDILK
IHAGPITKHGEIDYEAIVKLSDGFNGADLRNVCTEAGMFAIRADHDFVVQ
EDFMKAVRKVADSKKLESKLDYKPV
3D structure
PDB7w38 USP14-regulated allostery of the human proteasome by time-resolved cryo-EM.
ChainE
Resolution3.1 Å
3D
structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ATP E R291 R294 R277 R280
BS02 ATP E I135 P176 G177 T178 G179 K180 T181 L182 N280 I312 H316 G340 A341 I121 P162 G163 T164 G165 K166 T167 L168 N266 I298 H302 G326 A327
Gene Ontology
Molecular Function
GO:0005524 ATP binding
GO:0016887 ATP hydrolysis activity
Cellular Component
GO:0000502 proteasome complex

View graph for
Molecular Function
View graph for
Cellular Component
External links
PDB RCSB:7w38, PDBe:7w38, PDBj:7w38
PDBsum7w38
PubMed35477760
UniProtA0A087X2I1

[Back to BioLiP]