Structure of PDB 7w37 Chain E

Receptor sequence
>7w37E (length=375) Species: 9606 (Homo sapiens) [Search protein sequence]
KLLEHKEIDGRLKELREQLKELTKQYEKSENDLKALQSVGQIVGEVLKQL
TEEKFIVKATNGPRYVVGCRRQLDKSKLKPGTRVALDMTTLTIMRYLPRE
VDPLVYNMSHEDPGNVSYSEIGGLSEQIRELREVIELPLTNPELFQRVGI
IPPKGCLLYGPPGTGKTLLARAVASQLDCNFLKVVSSSIVDKYIGESARL
IREMFNYARDHQPCIIFMDEIDAIGGRRFSEGTSADREIQRTLMELLNQM
DGFDTLHRVKMIMATNRPDTLDPALLRPGRLDRKIHIDLPNEQARLDILK
IHAGPITKHGEIDYEAIVKLSDGFNGADLRNVCTEAGMFAIRADHDFVVQ
EDFMKAVRKVADSKKLESKLDYKPV
3D structure
PDB7w37 USP14-regulated allostery of the human proteasome by time-resolved cryo-EM.
ChainE
Resolution3.0 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ATP E R291 R294 R277 R280
BS02 ATP E G136 G177 T178 G179 K180 T181 L182 N280 I312 H316 G340 G122 G163 T164 G165 K166 T167 L168 N266 I298 H302 G326
Gene Ontology
Molecular Function
GO:0005524 ATP binding
GO:0016887 ATP hydrolysis activity
Cellular Component
GO:0000502 proteasome complex

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Molecular Function
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Cellular Component
External links
PDB RCSB:7w37, PDBe:7w37, PDBj:7w37
PDBsum7w37
PubMed35477760
UniProtA0A087X2I1

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