Structure of PDB 7w1m Chain E

Receptor sequence
>7w1mE (length=1226) Species: 9606 (Homo sapiens) [Search protein sequence]
MMDSSTFKRFTASIENILDNLEDMLLLGKHQLNELGSESAKIKAMGIMDK
LSTDKTVKVLNILEKNIQDGSKLSERLWRDLIMERVTKSADACLTTINIM
TSPNMPKAVYIEDVIERVIQYTKFHLQNTLYPQYDPVYRQRVIVMLYNKV
CDIVSSLSELLEIQLLTDTTILQVSSMGITPFFVENVSELQLCAIKLVTA
VFSRYEKHRQLILEEIFTSLARLPTSKRSLRNFRLPMYIQMVTALVLQLI
QCVVHLPDVVITNSYETAMRTAQNFLSIFLKKCGSKQGEEDYRPLFENFV
QDLLSTVNKPEWPAAELLLSLLGRLLVHQFSNKSTEMALRVASLDYLGTV
AARLRKDAVTSKMDEIQQLQKALLDYLDENTETDPSLVFSRKFYIAQWFR
DTTLETEKKEIETTGQIMHRAENRKKFLRSDTVDYDDACLIVRYLASMRP
FAQSFDIYLTQILRVLGENAIAVRTKAMKCLSEVVAVDPSILARLDMQRG
VHGRLMDNSTSVREAAVELLGRFVLCRPQLAEQYYDMLIERILDTGISVR
KRVIKILRDICIEQPTFPKITEMCVKMIRRVNDEEGIKKLVNETFQKLWF
TPTPHNDKEAMTRKILNITDVVAACRDTGYDWFEQLLQNLLKSEEDSSYK
PVKKACTQLVDNLVEHILKYEENSGRLVACITTLFLFSKIRPQLMVKHAM
TMQPYLTTKCSTQNDFMVICNVAKILELVVPLMEHPSETFLATIEEDLMK
LIIKYGMTVVQHCVSCLGAVVNKVTQNFKFVWACFNRYYGAISKLKSQHQ
EDPNNTSLLTNKPALLRSLFTVGALCRHFDFDLEDFKGNSKVNIKDKVLE
LLMYFTKHSDEEVQTKAIIGLGFAFIQHPSLMFEQEVKNLYNNILSDKNS
SVNLKIQVLKNLQTYLQEEDTRMQQADRDWKKVAKQEDLKEMGDVSSGMS
SSIMQLYLKQVLEAFFHTQSSVRHFALNVIALTLNQGLIHPVQCVPYLIA
MGTDPEPAMRNKADQQLVEIDKKYAGFIHMKAVAGMKMSYQVQQAINSAL
CSHLYSMIRGNRQHRRAFLISLLNLFDDTAKTDVTMLLYIADNLACFPYQ
TQEEPLFIMHHIDITLSVSGSNLLQSFKESLIEFANVSQGILLLLMLKQH
LKNLCGFSDSKIQKYSPSESAKVYDKAINRKTGVHFHPKQTLDFLRSDMA
NSKITEEVKRSIVKQYLDFKLLMEHL
3D structure
PDB7w1m Cryo-EM structure of human cohesin-CTCF complex
ChainE
Resolution6.5 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 dna E K1794 R1867 R2403 K2574 K479 R552 R1062 K1172
BS02 dna E K1467 T1825 I1862 S1863 K227 T510 I547 S548
Gene Ontology
Molecular Function
GO:0003682 chromatin binding
Biological Process
GO:0010468 regulation of gene expression
GO:0061780 mitotic cohesin loading

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Molecular Function
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Biological Process
External links
PDB RCSB:7w1m, PDBe:7w1m, PDBj:7w1m
PDBsum7w1m
PubMed37536339
UniProtQ6KC79|NIPBL_HUMAN Nipped-B-like protein (Gene Name=NIPBL)

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