Structure of PDB 7vza Chain E

Receptor sequence
>7vzaE (length=360) Species: 1946 (Streptomyces kasugaensis) [Search protein sequence]
HMALRVGIVYGTRPEAIKLAPLVLALDADPGFEPVIITTGDEINELFGLR
PRHNLDIMRQRLSAMASRIVGELGDPLLDELVDVAVVQGDTSTAFAAAYA
AACERIPVAHLEAGLRTGDRFEPFPEEINRRLITQLADLHFAPTADAAGN
LLAEGVRSDDVYVTGNTVIDAMHLVLDRELDAFTEGRQTVLLTMHRRESW
GIPMGRVAAAVAELCRSRPTLRFVIPLHPNPEVRRVFRSHLSSLTQVLLC
EPLRYSEFIRLMHRAVLVLTDSGGVQEEAPTLGKPVLVLRDRTERPEGIA
AGCARLVGTDPALIVKEVGRLLDDPEAYEAMRRPGIVCYGEGDAAARCLE
ALRERWLSSP
3D structure
PDB7vza KasQ an Epimerase Primes the Biosynthesis of Aminoglycoside Antibiotic Kasugamycin and KasF/H Acetyltransferases Inactivate Its Activity.
ChainE
Resolution2.58 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 5.1.3.14: UDP-N-acetylglucosamine 2-epimerase (non-hydrolyzing).
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 UDP E P13 H209 L267 Y269 F272 S286 G287 G288 E292 P14 H195 L253 Y255 F258 S272 G273 G274 E278
Gene Ontology
Molecular Function
GO:0000166 nucleotide binding
GO:0003824 catalytic activity
GO:0008761 UDP-N-acetylglucosamine 2-epimerase activity
GO:0016853 isomerase activity

View graph for
Molecular Function
External links
PDB RCSB:7vza, PDBe:7vza, PDBj:7vza
PDBsum7vza
PubMed35203422
UniProtA0A0K1H2R6

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