Structure of PDB 7vnp Chain E

Receptor sequence
>7vnpE (length=332) Species: 9606 (Homo sapiens) [Search protein sequence]
SAAHKRYRRLQNWVYNVLERPRGWAFVYHVFIFLLVFSCLVLSVLSTIQE
HQELANECLLILEFVMIVVFGLEYIVRVWSAGCCCRYRGWQGRFRFARKP
FCVIDFIVFVASVAVIAATSALRSMRFLQILRMVRMDRRGGTWKLLGSVV
YAHSKELITAWYIGFLVLIFASFLVYLAEKDANSDFSSYADSLWWGTITL
TTIGYGDKTPHTWLGRVLAAGFALLGISFFALPAGILGSGFALKVQEQHR
QKHFEKRRMPAANLIQAAWRLYSTDPAVKTVIRSIRILKFLVAKRKFKET
LRPYDVKDVIEQYSAGHLDMLGRIKSLQTRVD
3D structure
PDB7vnp Structural insights into the lipid and ligand regulation of a human neuronal KCNQ channel.
ChainE
Resolution2.79 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 PT5 E S235 K236 I239 S154 K155 I158
BS02 7YV E L306 S309 L225 S228 BindingDB: EC50=1600nM
BS03 PT5 E R93 R219 R220 G221 W224 K225 R20 R138 R139 G140 W143 K144
BS04 PT5 E R95 F99 R220 K333 R22 F26 R139 K252
BS05 7YV E W242 P314 W161 P233 BindingDB: EC50=1600nM
Gene Ontology
Molecular Function
GO:0005216 monoatomic ion channel activity
GO:0005249 voltage-gated potassium channel activity
GO:0005267 potassium channel activity
GO:0005515 protein binding
GO:0015144 carbohydrate transmembrane transporter activity
Biological Process
GO:0006811 monoatomic ion transport
GO:0006813 potassium ion transport
GO:0007605 sensory perception of sound
GO:0008643 carbohydrate transport
GO:0042472 inner ear morphogenesis
GO:0055085 transmembrane transport
GO:0071805 potassium ion transmembrane transport
Cellular Component
GO:0005886 plasma membrane
GO:0008076 voltage-gated potassium channel complex
GO:0009925 basal plasma membrane
GO:0016020 membrane
GO:0034702 monoatomic ion channel complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7vnp, PDBe:7vnp, PDBj:7vnp
PDBsum7vnp
PubMed34767770
UniProtP56696|KCNQ4_HUMAN Potassium voltage-gated channel subfamily KQT member 4 (Gene Name=KCNQ4)

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