Structure of PDB 7uw0 Chain E

Receptor sequence
>7uw0E (length=178) Species: 9606 (Homo sapiens) [Search protein sequence]
LIPIVVAYDIYSRLLRERIVCVMGPIDDSVASLVIAQLLFLQSESNKKPI
HMYINSPGGVVTAGLAIYDTMQYILNPICTWCVGQAASMGSLLLAAGTPG
MRHSLPNSRIMIHQPSATDIAIQAEEIMKLKKQLYNIYAKHTKQSLQVIE
SAMERDRYMSPMEAQEFGILDKVLVHPP
3D structure
PDB7uw0 Potent ClpP agonists with anticancer properties bind with improved structural complementarity and alter the mitochondrial N-terminome.
ChainE
Resolution2.8 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.4.21.92: endopeptidase Clp.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 P4I E L79 E82 H116 Y118 W146 V148 L14 E17 H51 Y53 W81 V83
BS02 P4I E I100 L104 S108 Y138 I35 L39 S43 Y73
Gene Ontology
Molecular Function
GO:0004176 ATP-dependent peptidase activity
GO:0004252 serine-type endopeptidase activity
Biological Process
GO:0006508 proteolysis

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Molecular Function
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Biological Process
External links
PDB RCSB:7uw0, PDBe:7uw0, PDBj:7uw0
PDBsum7uw0
PubMed36586405
UniProtQ16740|CLPP_HUMAN ATP-dependent Clp protease proteolytic subunit, mitochondrial (Gene Name=CLPP)

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