Structure of PDB 7umy Chain E

Receptor sequence

>7umyE (length=260) Species: 575584 (Acinetobacter baumannii ATCC 19606 = CIP 70.34 = JCM 6841) [Search protein sequence]

QGLLAGKRFLIAGVASKLSIAYGIAQALHREGAELAFTYPNEKLKKRVDE
FAEQFGSKLVFPCDVAVDAEIDNAFAELAKHWDGVDGVVHSIGFAPAHTL
DGDFTDVTDRDGFKIAHDISAYSFVAMARAAKPLLQARQGCLLTLTYQGS
ERVMPNYNVMGMAKASLEAGVRYLASSLGVDGIRVNAISAGPIRTLAASG
IKSFRKMLDANEKVAPLKRNVTIEEVGNAALFLCSPWASGITGEILYVDA
GFNTVGMSQS

3D structure

PDB

7umy An Iterative Approach Guides Discovery of the FabI Inhibitor Fabimycin, a Late-Stage Antibiotic Candidate with In Vivo Efficacy against Drug-Resistant Gram-Negative Infections

Chain

Resolution

2.74 Å

3D
structure

[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]

Enzymatic activity

Enzyme Commision number

1.3.1.9: enoyl-[acyl-carrier-protein] reductase (NADH).

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	NUC	E	F96 A97 L102 N158 Y159 A199 I203 F206	F94 A95 L100 N156 Y157 A197 I201 F204
BS02	NAD	E	G15 A17 S21 I22 P42 C65 D66 V67 S93 I94 G95 L147 T148 Y149 K166 A192 P194 I195 T197 L198	G13 A15 S19 I20 P40 C63 D64 V65 S91 I92 G93 L145 T146 Y147 K164 A190 P192 I193 T195 L196

Gene Ontology

	Molecular Function
GO:0000166	nucleotide binding
GO:0004318	enoyl-[acyl-carrier-protein] reductase (NADH) activity
GO:0016491	oxidoreductase activity

	Biological Process
GO:0006633	fatty acid biosynthetic process

View graph for
Molecular Function

View graph for
Biological Process

External links

PDB	RCSB:7umy, PDBe:7umy, PDBj:7umy
PDBsum	7umy
PubMed	36188352
UniProt	D0CAD5

[Back to BioLiP]