Structure of PDB 7uab Chain E

Receptor sequence
>7uabE (length=544) Species: 9606 (Homo sapiens) [Search protein sequence]
FGEQKDISEINLAAGLDLFQGDILLQNTRWTFPIPYILADNLGLNAKGAI
LYAFEMFRLKSCVDFKPYEGESSYIIFQQFDGCWSEVGDQHVGQNISIGQ
GCAYKAIIEHEILHALGFYHEQSRTDRDDYVNIWWDQILSGYQHNFDTYT
DLNTPYDYESLMHYQPFSFNKNASVPTITAKIPEFNSIIGQRLDFSAIDL
ERLNRMYNCTTTHTLLDHCTFEKANICGMIQGTRDDTDWAHQDSAQAGEV
DHTLLGQCTGAGYFMQFSTSSGSAEEAALLESRILYPKRKQQCLQFFYKM
TGSPSDRLVVWVRRDDSTGNVRKLVKVQTFQGDDDHNWKIAHVVLKEEQK
FRYLFQGTKGDPQNSTGGIYLDDITLTETPCPTGVWTVRNFSQVLENTSK
GDKLQSPRFYNSEGYGFGVTLYPNSRESSGYLRLAFHVCSGENDAILEWP
VENRQVIITILDQEPDVRNRMSSSMVFTTSKSHTSVIWDRPSRVGTYHTD
CNCFRSIDLGWSGFISHQMLKRRSFLKNDDLIIFVDFEDITHLS
3D structure
PDB7uab Helical ultrastructure of the metalloprotease meprin alpha in complex with a small molecule inhibitor.
ChainE
Resolution3.7 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.4.24.18: meprin A.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 FUC E T351 G352 T301 G302
BS02 CA E G282 D285 T287 D288 G232 D235 T237 D238
BS03 ZN E D58 H155 H159 H165 D22 H110 H114 H120
BS04 CA E T270 E272 T303 Y313 D422 T220 E222 T253 Y263 D372
Gene Ontology
Molecular Function
GO:0004222 metalloendopeptidase activity
GO:0008237 metallopeptidase activity
GO:0008270 zinc ion binding
Biological Process
GO:0006508 proteolysis
Cellular Component
GO:0016020 membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7uab, PDBe:7uab, PDBj:7uab
PDBsum7uab
PubMed36261433
UniProtQ16819|MEP1A_HUMAN Meprin A subunit alpha (Gene Name=MEP1A)

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