Structure of PDB 7uaa Chain E

Receptor sequence
>7uaaE (length=1430) Species: 10034 (Cricetus cricetus) [Search protein sequence]
MPLAFCGTENHSAAYRVDQGVLNNGCFVDALNVVPHVFLLFITFPILFIG
WGSQSSKVHIHHSTWLHFPGHNLRWILTFILLFVLVCEIAEGILSDGVTE
SRHLHLYMPAGMAFMAAITSVVYYHNIETSNFPKLLIALLIYWTLAFITK
TIKFVKFYDHAIGFSQLRFCLTGLLVILYGMLLLVEVNVIRVRRYIFFKT
PREVKPPEDLQDLGVRFLQPFVNLLSKGTYWWMNAFIKTAHKKPIDLRAI
AKLPIAMRALTNYQRLCVAFDAQARKDTQSPQGARAIWRALCHAFGRRLI
LSSTFRILADLLGFAGPLCIFGIVDHLGKENHVFQPKTQFLGVYFVSSQE
FLGNAYVLAVLLFLALLLQRTFLQASYYVAIETGINLRGAIQTKIYNKIM
HMSTSNLSMGEMTAGQICNLVAIDTNQLMWFFFLCPNLWTMPVQIIVGVI
LLYYILGVSALIGAAVIILLAPVQYFVATKLSQAQRTTLEHSNERLKQTN
EMLRGMKLLKLYAWESIFCSRVEVTRRKEMTSLRAFAVYTSISIFMNTAI
PIAAVLITFVGHVSFFKESDLSPSVAFASLSLFHILVTPLFLLSSVVRST
VKALVSVQKLSEFLSSAEIREEQCNFCVQIIGGFFTWTPDGIPTLSNITI
RIPRGQLTMIVGQVGCGKSSLLLATLGEMQKVSGAVFWNSNRGPVAYASQ
KPWLLNATVEENITFESPFNKQRYKMVIEACSLQPDIDILPHGDQTQIGE
RGINLSGGQRQRISVARALYQQTNVVFLDDPFSALDVHLSDHLMQAGILE
LLRDDKRTVVLVTHKLQYLPHADWIIAMKDGTIQREGTLKDFQRSECQLF
EHWKSSVLHQRAKIPWRACTKYLSSAGILLLSLLVFSQLLKHMVLVAIDY
WLAKWTDSALVDQSVYAMVFTLLCSLGIVLCLVTSVTVEWTGLKVAKRLH
RSLLNRIILAPMRFFETTPLGSILNRFSSDCNTIDQHIPSTLECLSRSTL
LCVSALTVISYVTPVFLVALLPLAVVCYFIQKYFRVASRDLQQLDDTTQL
PLVSHFAETVEGLTTIRAFRYEARFQQKLLEYTDSNNIASLFLTAANRWL
EVCMEYIGACVVLIAAATSISNSLHRELSAGLVGLGLTYALMVSNYLNWM
VRNLADMEIQLGAVKRIHALLKTEAESYEGLLAPSLIPKNWPDQGKIQIQ
NLSVRYDSSLKPVLKHVNTLISPGQKIGICGRTGSGKSSFSLAFFRMVDM
FEGRIIIDGIDIAKLPLHTLRSRLSIILQDPVLFSGTIRFNLDPEKKCSD
STLWEALEIAQLKLVVKALPGGLDAIITEGGENFSQGQRQLFCLARAFVR
KTSIFIMDEATASIDMATENILQKVVMTAFADRTVVTIAHRVHTILSADL
VMVLKRGAILEFDKPETLLSQKDSVFASFV
3D structure
PDB7uaa Ligand-mediated Structural Dynamics of a Mammalian Pancreatic K ATP Channel.
ChainE
Resolution5.7 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ATP E G716 S720 S721 G665 S669 S670
Gene Ontology
Molecular Function
GO:0005267 potassium channel activity
GO:0005524 ATP binding
GO:0008281 sulfonylurea receptor activity
GO:0016887 ATP hydrolysis activity
GO:0042626 ATPase-coupled transmembrane transporter activity
GO:0140359 ABC-type transporter activity
Biological Process
GO:0006813 potassium ion transport
GO:0055085 transmembrane transport
GO:0071805 potassium ion transmembrane transport
Cellular Component
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0032991 protein-containing complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7uaa, PDBe:7uaa, PDBj:7uaa
PDBsum7uaa
PubMed35964676
UniProtQ09427|ABCC8_CRICR ATP-binding cassette sub-family C member 8 (Gene Name=ABCC8)

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