Structure of PDB 7u66 Chain E

Receptor sequence
>7u66E (length=474) Species: 511145 (Escherichia coli str. K-12 substr. MG1655) [Search protein sequence]
QIDFRKKINWHRRYRSPQGVKTEHEILRIFESDRGRIINSPAIRRLQQKT
QVFPAVRTRLTHSMEVQQVGRYIAKEILSRLKELKLLEAYGLDELTGPFE
SIVEMSCLMHDIGNPPFGHFGEAAINDWFRQRLHPEDAESQPLDRCSVAA
LRLREEPLNELRRKIRQDLCHFEGNAQGIRLVHTLMRMNLTWAQVGGILK
YTRPAWWRGETPETHHYLMKKPGYYLSEEAYIARLRKELNLALYSRFPLT
WIMEAADDISYCVADLEDAVEKRIFTVEQLYHHLHEAWFSLVVENAWEST
EDQFFMYLRVNTLNKLVPYAAQRFIDNLPAIFAGTFNHALLASECSDLLK
LYKNVAVKHVFSHPDVERLELQGYRVISGLLEIYRPLLSLSLSDFTELVE
KERVKRFPIESRLFHKLSTRHRLAYVEAVSKLPSDSPEFPLWEYYYRCRL
LQDYISGMTDLYAWDEYRRLMAVE
3D structure
PDB7u66 Mechanism by which T7 bacteriophage protein Gp1.2 inhibits Escherichia coli dGTPase.
ChainE
Resolution3.1 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.1.5.1: dGTPase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 DGT E Y272 F391 Y261 F361
BS02 MG E H69 H117 D268 H62 H110 D257
Gene Ontology
Molecular Function
GO:0000287 magnesium ion binding
GO:0003697 single-stranded DNA binding
GO:0003924 GTPase activity
GO:0008832 dGTPase activity
GO:0016787 hydrolase activity
GO:0016793 triphosphoric monoester hydrolase activity
GO:0030145 manganese ion binding
GO:0042802 identical protein binding
GO:0050897 cobalt ion binding
Biological Process
GO:0006203 dGTP catabolic process
GO:0015949 nucleobase-containing small molecule interconversion
GO:0043099 pyrimidine deoxyribonucleoside salvage

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Molecular Function
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Biological Process
External links
PDB RCSB:7u66, PDBe:7u66, PDBj:7u66
PDBsum7u66
PubMed36067314
UniProtP15723|DGTP_ECOLI Deoxyguanosinetriphosphate triphosphohydrolase (Gene Name=dgt)

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