Structure of PDB 7u52 Chain E

Receptor sequence
>7u52E (length=97) Species: 9606 (Homo sapiens) [Search protein sequence]
PHRYRPGTVALREIRRYQKSTELLIRKLPFQRLVREIAQDFKTDLRFQSS
AVMALQEASEAYLVGLFEDTNLAAIHAKRVTIMPKDIQLARRIRGER
3D structure
PDB7u52 Structural basis for APE1 processing DNA damage in the nucleosome.
ChainE
Resolution3.4 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 dna E H39 R40 Y41 G44 V46 R49 R63 K64 L65 P66 R69 H2 R3 Y4 G7 V9 R12 R26 K27 L28 P29 R32
BS02 dna E R40 R42 T45 R72 R83 F84 V117 T118 M120 R3 R5 T8 R35 R46 F47 V80 T81 M83
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0005515 protein binding
GO:0030527 structural constituent of chromatin
GO:0046982 protein heterodimerization activity
Biological Process
GO:0006325 chromatin organization
GO:0006334 nucleosome assembly
Cellular Component
GO:0000786 nucleosome
GO:0005576 extracellular region
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005694 chromosome
GO:0070062 extracellular exosome

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Cellular Component
External links
PDB RCSB:7u52, PDBe:7u52, PDBj:7u52
PDBsum7u52
PubMed36104361
UniProtQ71DI3|H32_HUMAN Histone H3.2 (Gene Name=H3C15)

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