Structure of PDB 7u2x Chain E

Receptor sequence
>7u2xE (length=1427) Species: 10034 (Cricetus cricetus) [Search protein sequence]
MPLAFCGTENHSAAYRVDQGVLNNGCFVDALNVVPHVFLLFITFPILFIG
WGSQHSTWLHFPGHNLRWILTFILLFVLVCEIAEGILSDGVTESRHLHLY
MPAGMAFMAAITSVVYYHNIETSNFPKLLIALLIYWTLAFITKTIKFVKF
YDHAIGFSQLRFCLTGLLVILYGMLLLVEVNVIRVRRYIFFKTPREVKPP
EDLQDLGVRFLQPFVNLLSKGTYWWMNAFIKTAHKKPIDLRAIAKLPIAM
RALTNYQRLCVAFDAQARKDTQSPQGARAIWRALCHAFGRRLILSSTFRI
LADLLGFAGPLCIFGIVDHLGKENHVFQPKTQFLGVYFVSSQEFLGNAYV
LAVLLFLALLLQRTFLQASYYVAIETGINLRGAIQTKIYNKIMHMSTSNL
SMGEMTAGQICNLVAIDTNQLMWFFFLCPNLWTMPVQIIVGVILLYYILG
VSALIGAAVIILLAPVQYFVATKLSQAQRTTLEHSNERLKQTNEMLRGMK
LLKLYAWESIFCSRVEVTRRKEMTSLRAFAVYTSISIFMNTAIPIAAVLI
TFVGHVSFFKESDLSPSVAFASLSLFHILVTPLFLLSSVVRSTVKALVSV
QKLSEFLSSAEIREEQCDNFCVQIIGGFFTWTPDGIPTLSNITIPRGQLT
MIVGQVGCGKSSLLLATLGEMQKVSGAVFWNSNLSRGPVAYASQKPWLLN
ATVEENITFESPFNKQRYKMVIEACSLQPDIDILPHGDQTQIGERGINLS
GGQRQRISVARALYQQTNVVFLDDPFSALDVHLSDHLMQAGILELLRDDK
RTVVLVTHKLQYLPHADWIIAMKDGTIQREGTLKDFQRSECQLFEHWKTL
LSSVLHQRAKIPWRACTKYLSSAGILLLSLLVFSQLLKHMVLVAIDYWLA
KWTDSALVDQSVYAMVFTLLCSLGIVLCLVTSVTVEWTGLKVAKRLHRSL
LNRIILAPMRFFETTPLGSILNRFSSDCNTIDQHIPSTLECLSRSTLLCV
SALTVISYVTPVFLVALLPLAVVCYFIQKYFRVASRDLQQLDDTTQLPLV
SHFAETVEGLTTIRAFRYEARFQQKLLEYTDSNNIASLFLTAANRWLEVC
MEYIGACVVLIAAATSISNSLHRELSAGLVGLGLTYALMVSNYLNWMVRN
LADMEIQLGAVKRIHALLKTEAESYEGLLAPSLIPKNWPDQGKIQIQNLS
VRYDSSLKPVLKHVNTLISPGQKIGICGRTGSGKSSFSLAFFRMVDMFEG
RIIIDGIDIAKLPLHTLRSRLSIILQDPVLFSGTIRFNLDPEKKCSDSTL
WEALEIAQLKLVVKALPGGLDAIITEGGENFSQGQRQLFCLARAFVRKTS
IFIMDEATASIDMATENILQKVVMTAFADRTVVTIAHRVHTILSADLVMV
LKRGAILEFDKPETLLSQKDSVFASFV
3D structure
PDB7u2x Ligand-mediated Structural Dynamics of a Mammalian Pancreatic K ATP Channel.
ChainE
Resolution4.1 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 P5S E F79 F83 L225 R298 F305 L368 T371 F372 Y1254 F72 F76 L218 R291 F298 L361 T364 F365 Y1103
BS02 ATP E N406 W688 G716 G718 K719 S720 S721 Q775 N399 W631 G657 G659 K660 S661 S662 Q694
Gene Ontology
Molecular Function
GO:0005267 potassium channel activity
GO:0005524 ATP binding
GO:0008281 sulfonylurea receptor activity
GO:0016887 ATP hydrolysis activity
GO:0042626 ATPase-coupled transmembrane transporter activity
GO:0140359 ABC-type transporter activity
Biological Process
GO:0006813 potassium ion transport
GO:0055085 transmembrane transport
GO:0071805 potassium ion transmembrane transport
Cellular Component
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0032991 protein-containing complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7u2x, PDBe:7u2x, PDBj:7u2x
PDBsum7u2x
PubMed35964676
UniProtQ09427|ABCC8_CRICR ATP-binding cassette sub-family C member 8 (Gene Name=ABCC8)

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