Structure of PDB 7u24 Chain E

Receptor sequence

>7u24E (length=1427) Species: 10034 (Cricetus cricetus)

MPLAFCGTENHSAAYRVDQGVLNNGCFVDALNVVPHVFLLFITFPILFIG
WGSQSSKVHIHHSTWLHFPGHNLRWILTFILLFVLVCEIAEGILSDGVTE
SRHLHLYMPAGMAFMAAITSVVYYHNIETSNFPKLLIALLIYWTLAFITK
TIKFVKFYDHAIGFSQLRFCLTGLLVILYGMLLLVEVNVIRVRRYIFFKT
PREVKPPEDLQDLGVRFLQPFVNLLSKGTYWWMNAFIKTAHKKPIDLRAI
AKLPIAMRALTNYQRLCVAFDAQARKDTQSPQGARAIWRALCHAFGRRLI
LSSTFRILADLLGFAGPLCIFGIVDHLGKENHVFQPKTQFLGVYFVSSQE
FLGNAYVLAVLLFLALLLQRTFLQASYYVAIETGINLRGAIQTKIYNKIM
MSTSNLSMGEMTAGQICNLVAIDTNQLMWFFFLCPNLWTMPVQIIVGVIL
LYYILGVSALIGAAVIILLAPVQYFVATKLSQAQRTTLEHSNERLKQTNE
MLRGMKLLKLYAWESIFCSRVEVTRRKEMTSLRAFAVYTSISIFMNTAIP
IAAVLITFVGHVSFFKESDLSPSVAFASLSLFHILVTPLFLLSSVVRSTV
KALVSVQKLSEFLSSAEIRECVQIIGGFFTWTPDGIPTLSNITIRIPRGQ
LTMIVGQVGCGKSSLLLATLGEMQKVSGAVFWNSNRSRGPVAYASQKPWL
LNATVEENITFESPFNKQRYKMVIEACSLQPDIDILPHGDQTQIGERGIN
LSGGQRQRISVARALYQQTNVVFLDDPFSALDVHLSDHLMQAGILELLRD
DKRTVVLVTHKLQYLPHADWIIAMKDGTIQREGTLKDFQRSECQLFEHWL
SSVLHQRAKIPWRACTKYLSSAGILLLSLLVFSQLLKHMVLVAIDYWLAK
WTDSALVLDQSVYAMVFTLLCSLGIVLCLVTSVTVEWTGLKVAKRLHRSL
LNRIILAPMRFFETTPLGSILNRFSSDCNTIDQHIPSTLECLSRSTLLCV
SALTVISYVTPVFLVALLPLAVVCYFIQKYFRVASRDLQQLDDTTQLPLV
SHFAETVEGLTTIRAFRYEARFQQKLLEYTDSNNIASLFLTAANRWLEVC
MEYIGACVVLIAAATSISNSLHRELSAGLVGLGLTYALMVSNYLNWMVRN
LADMEIQLGAVKRIHALLKTEAESYEGLLAPSLIPKNWPDQGKIQIQNLS
VRYDSSLKPVLKHVNTLISPGQKIGICGRTGSGKSSFSLAFFRMVDMFEG
RIIIDGIDIAKLPLHTLRSRLSIILQDPVLFSGTIRFNLDPEKKCSDSTL
WEALEIAQLKLVVKALPGGLDAIITEGGENFSQGQRQLFCLARAFVRKTS
IFIMDEATASIDMATENILQKVVMTAFADRTVVTIAHRVHTILSADLVMV
LKRGAILEFDKPETLLSQKDSVFASFV

3D structure

• PDB: 7u24 Ligand-mediated Structural Dynamics of a Mammalian Pancreatic K ATP Channel.
• Chain: E
• Resolution: 3.58 Å

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	P5S	E	I46 F132 K134	I46 F132 K134
BS02	GBM	E	R306 Y377 F433 L434 P589 L592 L1241 R1246	R306 Y377 F432 L433 P588 L591 L1090 R1095
BS03	ATP	E	W688 G716 C717 G718 K719 S720 Q775	W631 G659 C660 G661 K662 S663 Q696
BS04	P5S	E	I76 F79 K227 L301 F305 L368 T371 F372	I76 F79 K227 L301 F305 L368 T371 F372

Gene Ontology

Molecular Function

• GO:0005267 potassium channel activity
• GO:0005524 ATP binding
• GO:0008281 sulfonylurea receptor activity
• GO:0016887 ATP hydrolysis activity
• GO:0042626 ATPase-coupled transmembrane transporter activity
• GO:0140359 ABC-type transporter activity

Biological Process

• GO:0006813 potassium ion transport
• GO:0055085 transmembrane transport
• GO:0071805 potassium ion transmembrane transport

Cellular Component

• GO:0005886 plasma membrane
• GO:0016020 membrane
• GO:0032991 protein-containing complex

External links

• PDB: RCSB:7u24, PDBe:7u24, PDBj:7u24
• PDBsum: 7u24
• PubMed: 35964676
• UniProt: Q09427|ABCC8_CRICR ATP-binding cassette sub-family C member 8 (Gene Name=ABCC8)