Structure of PDB 7u1s Chain E

Receptor sequence

>7u1sE (length=1439) Species: 10034 (Cricetus cricetus)

MPLAFCGTENHSAAYRVDQGVLNNGCFVDALNVVPHVFLLFITFPILFIG
WGSQSSKVHIHHSTWLHFPGHNLRWILTFILLFVLVCEIAEGILSDGVTE
SRHLHLYMPAGMAFMAAITSVVYYHNIETSNFPKLLIALLIYWTLAFITK
TIKFVKFYDHAIGFSQLRFCLTGLLVILYGMLLLVEVNVIRVRRYIFFKT
PREVKPPEDLQDLGVRFLQPFVNLLSKGTYWWMNAFIKTAHKKPIDLRAI
AKLPIAMRALTNYQRLCVAFDAQARKDTQSPQGARAIWRALCHAFGRRLI
LSSTFRILADLLGFAGPLCIFGIVDHLGKENHVFQPKTQFLGVYFVSSQE
FLGNAYVLAVLLFLALLLQRTFLQASYYVAIETGINLRGAIQTKIYNKIM
HMSTSNLSMGEMTAGQICNLVAIDTNQLMWFFFLCPNLWTMPVQIIVGVI
LLYYILGVSALIGAAVIILLAPVQYFVATKLSQAQRTTLEHSNERLKQTN
EMLRGMKLLKLYAWESIFCSRVEVTRRKEMTSLRAFAVYTSISIFMNTAI
PIAAVLITFVGHVSFFKESDLSPSVAFASLSLFHILVTPLFLLSSVVRST
VKALVSVQKLSEFLSSAEIREEQCAPNFCVQIIGGFFTWTPDGIPTLSNI
TIRIPRGQLTMIVGQVGCGKSSLLLATLGEMQKVSGAVFWNSNSRGPVAY
ASQKPWLLNATVEENITFESPFNKQRYKMVIEACSLQPDIDILPHGDQTQ
IGERGINLSGGQRQRISVARALYQQTNVVFLDDPFSALDVHLSDHLMQAG
ILELLRDDKRTVVLVTHKLQYLPHADWIIAMKDGTIQREGTLKDFQRSEC
QLFLSSVLHQRAKIPWRACTKYLSSAGILLLSLLVFSQLLKHMVLVAIDY
WLAKWTDSALVCSLSQECDLDQSVYAMVFTLLCSLGIVLCLVTSVTVEWT
GLKVAKRLHRSLLNRIILAPMRFFETTPLGSILNRFSSDCNTIDQHIPST
LECLSRSTLLCVSALTVISYVTPVFLVALLPLAVVCYFIQKYFRVASRDL
QQLDDTTQLPLVSHFAETVEGLTTIRAFRYEARFQQKLLEYTDSNNIASL
FLTAANRWLEVCMEYIGACVVLIAAATSISNSLHRELSAGLVGLGLTYAL
MVSNYLNWMVRNLADMEIQLGAVKRIHALLKTEAESYEGLLAPSLIPKNW
PDQGKIQIQNLSVRYDSSLKPVLKHVNTLISPGQKIGICGRTGSGKSSFS
LAFFRMVDMFEGRIIIDGIDIAKLPLHTLRSRLSIILQDPVLFSGTIRFN
LDPEKKCSDSTLWEALEIAQLKLVVKALPGGLDAIITEGGENFSQGQRQL
FCLARAFVRKTSIFIMDEATASIDMATENILQKVVMTAFADRTVVTIAHR
VHTILSADLVMVLKRGAILEFDKPETLLSQKDSVFASFV

3D structure

• PDB: 7u1s Ligand-mediated Structural Dynamics of a Mammalian Pancreatic K ATP Channel.
• Chain: E
• Resolution: 3.8 Å

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	P5S	E	F132 I137	F132 I137
BS02	BJX	E	R306 Y377 I381 L434 L592 N1245 R1246 W1297	R306 Y377 I381 L434 L592 N1106 R1107 W1158
BS03	P5S	E	I76 F79 I80 L82 F83 R298 F305 L368 T371 F372	I76 F79 I80 L82 F83 R298 F305 L368 T371 F372
BS04	ATP	E	N406 W688 V715 G716 C717 G718 K719 S720 S721 Q775	N406 W639 V666 G667 C668 G669 K670 S671 S672 Q703

Gene Ontology

Molecular Function

• GO:0005267 potassium channel activity
• GO:0005524 ATP binding
• GO:0008281 sulfonylurea receptor activity
• GO:0016887 ATP hydrolysis activity
• GO:0042626 ATPase-coupled transmembrane transporter activity
• GO:0140359 ABC-type transporter activity

Biological Process

• GO:0006813 potassium ion transport
• GO:0055085 transmembrane transport
• GO:0071805 potassium ion transmembrane transport

Cellular Component

• GO:0005886 plasma membrane
• GO:0016020 membrane
• GO:0032991 protein-containing complex

External links

• PDB: RCSB:7u1s, PDBe:7u1s, PDBj:7u1s
• PDBsum: 7u1s
• PubMed: 35964676
• UniProt: Q09427|ABCC8_CRICR ATP-binding cassette sub-family C member 8 (Gene Name=ABCC8)