Structure of PDB 7u1q Chain E

Receptor sequence
>7u1qE (length=1434) Species: 10034 (Cricetus cricetus) [Search protein sequence]
MPLAFCGTENHSAAYRVDQGVLNNGCFVDALNVVPHVFLLFITFPILFIG
WGSQSSKVHIHHSTWLHFPGHNLRWILTFILLFVLVCEIAEGILSDGVTE
SRHLHLYMPAGMAFMAAITSVVYYHNIETSNFPKLLIALLIYWTLAFITK
TIKFVKFYDHAIGFSQLRFCLTGLLVILYGMLLLVEVNVIRVRRYIFFKT
PREVKPPEDLQDLGVRFLQPFVNLLSKGTYWWMNAFIKTAHKKPIDLRAI
AKLPIAMRALTNYQRLCVAFDAQARKDTQSPQGARAIWRALCHAFGRRLI
LSSTFRILADLLGFAGPLCIFGIVDHLGKENHVFQPKTQFLGVYFVSSQE
FLGNAYVLAVLLFLALLLQRTFLQASYYVAIETGINLRGAIQTKIYNKIM
HMSTSNLSMGEMTAGQICNLVAIDTNQLMWFFFLCPNLWTMPVQIIVGVI
LLYYILGVSALIGAAVIILLAPVQYFVATKLSQAQRTTLEHSNERLKQTN
EMLRGMKLLKLYAWESIFCSRVEVTRRKEMTSLRAFAVYTSISIFMNTAI
PIAAVLITFVGHVSFFKESDLSPSVAFASLSLFHILVTPLFLLSSVVRST
VKALVSVQKLSEFLSSAEIRENFCVQIIGGFFTWTPDGIPTLSNITIRIP
RGQLTMIVGQVGCGKSSLLLATLGEMQKVSGAVFWNSNSRGPVAYASQKP
WLLNATVEENITFESPFNKQRYKMVIEACSLQPDIDILPHGDQTQIGERG
INLSGGQRQRISVARALYQQTNVVFLDDPFSALDVHLSDHLMQAGILELL
RDDKRTVVLVTHKLQYLPHADWIIAMKDGTIQREGTLKDFQRSECQLFLS
SVLHQRAKIPWRACTKYLSSAGILLLSLLVFSQLLKHMVLVAIDYWLAKW
TDSALVCSLSQECDLDQSVYAMVFTLLCSLGIVLCLVTSVTVEWTGLKVA
KRLHRSLLNRIILAPMRFFETTPLGSILNRFSSDCNTIDQHIPSTLECLS
RSTLLCVSALTVISYVTPVFLVALLPLAVVCYFIQKYFRVASRDLQQLDD
TTQLPLVSHFAETVEGLTTIRAFRYEARFQQKLLEYTDSNNIASLFLTAA
NRWLEVCMEYIGACVVLIAAATSISNSLHRELSAGLVGLGLTYALMVSNY
LNWMVRNLADMEIQLGAVKRIHALLKTEAESYEGLLAPSLIPKNWPDQGK
IQIQNLSVRYDSSLKPVLKHVNTLISPGQKIGICGRTGSGKSSFSLAFFR
MVDMFEGRIIIDGIDIAKLPLHTLRSRLSIILQDPVLFSGTIRFNLDPEK
KCSDSTLWEALEIAQLKLVVKALPGGLDAIITEGGENFSQGQRQLFCLAR
AFVRKTSIFIMDEATASIDMATENILQKVVMTAFADRTVVTIAHRVHTIL
SADLVMVLKRGAILEFDKPETLLSQKDSVFASFV
3D structure
PDB7u1q Ligand-mediated Structural Dynamics of a Mammalian Pancreatic K ATP Channel.
ChainE
Resolution3.9 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 P5S E P45 F132 P45 F132
BS02 BJX E Y377 L434 N437 L592 S595 N1245 R1246 W1297 R1300 Y377 L434 N437 L592 S595 N1101 R1102 W1153 R1156
BS03 ATP E N406 W688 G716 C717 G718 K719 S720 S721 Q775 N406 W634 G662 C663 G664 K665 S666 S667 Q698
Gene Ontology
Molecular Function
GO:0005267 potassium channel activity
GO:0005524 ATP binding
GO:0008281 sulfonylurea receptor activity
GO:0016887 ATP hydrolysis activity
GO:0042626 ATPase-coupled transmembrane transporter activity
GO:0140359 ABC-type transporter activity
Biological Process
GO:0006813 potassium ion transport
GO:0055085 transmembrane transport
GO:0071805 potassium ion transmembrane transport
Cellular Component
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0032991 protein-containing complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7u1q, PDBe:7u1q, PDBj:7u1q
PDBsum7u1q
PubMed35964676
UniProtQ09427|ABCC8_CRICR ATP-binding cassette sub-family C member 8 (Gene Name=ABCC8)

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