Structure of PDB 7u1e Chain E

Receptor sequence
>7u1eE (length=1432) Species: 10034 (Cricetus cricetus) [Search protein sequence]
MPLAFCGTENHSAAYRVDQGVLNNGCFVDALNVVPHVFLLFITFPILFIG
WHIHHSTWLHFPGHNLRWILTFILLFVLVCEIAEGILSDGVTESRHLHLY
MPAGMAFMAAITSVVYYHNIETSNFPKLLIALLIYWTLAFITKTIKFVKF
YDHAIGFSQLRFCLTGLLVILYGMLLLVEVNVIRVRRYIFFKTPREVKPP
EDLQDLGVRFLQPFVNLLSKGTYWWMNAFIKTAHKKPIDLRAIAKLPIAM
RALTNYQRLCVAFDAQARKDTQSPQGARAIWRALCHAFGRRLILSSTFRI
LADLLGFAGPLCIFGIVDHLGKENHVFQPKTQFLGVYFVSSQEFLGNAYV
LAVLLFLALLLQRTFLQASYYVAIETGINLRGAIQTKIYNKIMHMSTSNL
SMGEMTAGQICNLVAIDTNQLMWFFFLCPNLWTMPVQIIVGVILLYYILG
VSALIGAAVIILLAPVQYFVATKLSQAQRTTLEHSNERLKQTNEMLRGMK
LLKLYAWESIFCSRVEVTRRKEMTSLRAFAVYTSISIFMNTAIPIAAVLI
TFVGHVSFFKESDLSPSVAFASLSLFHILVTPLFLLSSVVRSTVKALVSV
QKLSEFLSSAEIREEQCVQIIGGFFTWTPDGIPTLSNITIRIPRGQLTMI
VGQVGCGKSSLLLATLGEMQKVSGAVFWNSNLDIRSRGPVAYASQKPWLL
NATVEENITFESPFNKQRYKMVIEACSLQPDIDILPHGDQTQIGERGINL
SGGQRQRISVARALYQQTNVVFLDDPFSALDVHLSDHLMQAGILELLRDD
KRTVVLVTHKLQYLPHADWIIAMKDGTIQREGTLKDFQRSECQLFEHWSE
EDDNLSSVLHQRAKIPWRACTKYLSSAGILLLSLLVFSQLLKHMVLVAID
YWLAKWTDSALVLDQSVYAMVFTLLCSLGIVLCLVTSVTVEWTGLKVAKR
LHRSLLNRIILAPMRFFETTPLGSILNRFSSDCNTIDQHIPSTLECLSRS
TLLCVSALTVISYVTPVFLVALLPLAVVCYFIQKYFRVASRDLQQLDDTT
QLPLVSHFAETVEGLTTIRAFRYEARFQQKLLEYTDSNNIASLFLTAANR
WLEVCMEYIGACVVLIAAATSISNSLHRELSAGLVGLGLTYALMVSNYLN
WMVRNLADMEIQLGAVKRIHALLKTEAESYEGLLAPSLIPKNWPDQGKIQ
IQNLSVRYDSSLKPVLKHVNTLISPGQKIGICGRTGSGKSSFSLAFFRMV
DMFEGRIIIDGIDIAKLPLHTLRSRLSIILQDPVLFSGTIRFNLDPEKKC
SDSTLWEALEIAQLKLVVKALPGGLDAIITEGGENFSQGQRQLFCLARAF
VRKTSIFIMDEATASIDMATENILQKVVMTAFADRTVVTIAHRVHTILSA
DLVMVLKRGAILEFDKPETLLSQKDSVFASFV
3D structure
PDB7u1e Ligand-mediated Structural Dynamics of a Mammalian Pancreatic K ATP Channel.
ChainE
Resolution4.52 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ATP E W688 G716 C717 G718 K719 S720 Q775 W627 G655 C656 G657 K658 S659 Q695
Gene Ontology
Molecular Function
GO:0005267 potassium channel activity
GO:0005524 ATP binding
GO:0008281 sulfonylurea receptor activity
GO:0016887 ATP hydrolysis activity
GO:0042626 ATPase-coupled transmembrane transporter activity
GO:0140359 ABC-type transporter activity
Biological Process
GO:0006813 potassium ion transport
GO:0055085 transmembrane transport
GO:0071805 potassium ion transmembrane transport
Cellular Component
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0032991 protein-containing complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7u1e, PDBe:7u1e, PDBj:7u1e
PDBsum7u1e
PubMed35964676
UniProtQ09427|ABCC8_CRICR ATP-binding cassette sub-family C member 8 (Gene Name=ABCC8)

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