Structure of PDB 7u1a Chain E

Receptor sequence
>7u1aE (length=337) Species: 4932 (Saccharomyces cerevisiae) [Search protein sequence]
WVDKYRPKSLNALSHNEELTNFLKSLSDQPRDLPHLLLYGPNGTGKKTRC
MALLESIFGPGVYRLKIDVRQFVTASNRKLELNVVSSPYHLEITPSDMGN
NDRIVIQELLKEVAQMERYKCVIINEANSLTKDAQAALRRTMEKYSKNIR
LIMVCDSMSPIIAPIKSRCLLIRCPAPSDSEISTILSDVVTNERIQLETK
DILKRIAQASNGNLRVSLLMLESMALNNELALKSSSPIIKPDWIIVIHKL
TRKIVKERSVNSLIECRAVLYDLLAHCIPANIILKELTFSLLDVETLNTT
NKSSIIEYSSVFDERLSLGNKAIFHLEGFIAKVMCCL
3D structure
PDB7u1a A second DNA binding site on RFC facilitates clamp loading at gapped or nicked DNA.
ChainE
Resolution3.3 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 dna E T77 N104 T74 N101
BS02 AGS E E159 R184 E143 R168
BS03 ADP E V5 R9 P10 L16 S17 H18 N45 G46 G48 K49 K50 L230 R231 V2 R6 P7 L13 S14 H15 N42 G43 G45 K46 K47 L214 R215
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003689 DNA clamp loader activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016887 ATP hydrolysis activity
Biological Process
GO:0000077 DNA damage checkpoint signaling
GO:0006260 DNA replication
GO:0006261 DNA-templated DNA replication
GO:0006271 DNA strand elongation involved in DNA replication
GO:0006272 leading strand elongation
GO:0006281 DNA repair
GO:0007062 sister chromatid cohesion
GO:0007064 mitotic sister chromatid cohesion
GO:0090618 DNA clamp unloading
Cellular Component
GO:0005634 nucleus
GO:0005663 DNA replication factor C complex
GO:0031389 Rad17 RFC-like complex
GO:0031390 Ctf18 RFC-like complex
GO:0031391 Elg1 RFC-like complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7u1a, PDBe:7u1a, PDBj:7u1a
PDBsum7u1a
PubMed35731107
UniProtP38251|RFC5_YEAST Replication factor C subunit 5 (Gene Name=RFC5)

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