Structure of PDB 7tyt Chain E

Receptor sequence

>7tytE (length=1425) Species: 10034 (Cricetus cricetus)

MPLAFCGTENHSAAYRVDQGVLNNGCFVDALNVVPHVFLLFITFPILFIG
WIHHSTWLHFPGHNLRWILTFILLFVLVCEIAEGILSDGVTESRHLHLYM
PAGMAFMAAITSVVYYHNIETSNFPKLLIALLIYWTLAFITKTIKFVKFY
DHAIGFSQLRFCLTGLLVILYGMLLLVEVNVIRVRRYIFFKTPREVKPPE
DLQDLGVRFLQPFVNLLSKGTYWWMNAFIKTAHKKPIDLRAIAKLPIAMR
ALTNYQRLCVAFDAQARKDTQSPQGARAIWRALCHAFGRRLILSSTFRIL
ADLLGFAGPLCIFGIVDHLGKENHVFQPKTQFLGVYFVSSQEFLGNAYVL
AVLLFLALLLQRTFLQASYYVAIETGINLRGAIQTKIYNKIMHMSTSNLS
MGEMTAGQICNLVAIDTNQLMWFFFLCPNLWTMPVQIIVGVILLYYILGV
SALIGAAVIILLAPVQYFVATKLSQAQRTTLEHSNERLKQTNEMLRGMKL
LKLYAWESIFCSRVEVTRRKEMTSLRAFAVYTSISIFMNTAIPIAAVLIT
FVGHVSFFKESDLSPSVAFASLSLFHILVTPLFLLSSVVRSTVKALVSVQ
KLSEFLSSAEIREEQCDADNFCVQIIGGFFTWTPDGIPTLSNITIPRGQL
TMIVGQVGCGKSSLLLATLGEMQKVSGAVFWNSNLSRGPVAYASQKPWLL
NATVEENITFESPFNKQRYKMVIEACSLQPDIDILPHGDQTQIGERGINL
SGGQRQRISVARALYQQTNVVFLDDPFSALDVHLSDHLMQAGILELLRDD
KRTVVLVTHKLQYLPHADWIIAMKDGTIQREGTLKDFQRSECQLFEHWLS
SVLHQRAKIPWRACTKYLSSAGILLLSLLVFSQLLKHMVLVAIDYWLAKW
TDSALVDQSVYAMVFTLLCSLGIVLCLVTSVTVEWTGLKVAKRLHRSLLN
RIILAPMRFFETTPLGSILNRFSSDCNTIDQHIPSTLECLSRSTLLCVSA
LTVISYVTPVFLVALLPLAVVCYFIQKYFRVASRDLQQLDDTTQLPLVSH
FAETVEGLTTIRAFRYEARFQQKLLEYTDSNNIASLFLTAANRWLEVCME
YIGACVVLIAAATSISNSLHRELSAGLVGLGLTYALMVSNYLNWMVRNLA
DMEIQLGAVKRIHALLKTEAESYEGLLAPSLIPKNWPDQGKIQIQNLSVR
YDSSLKPVLKHVNTLISPGQKIGICGRTGSGKSSFSLAFFRMVDMFEGRI
IIDGIDIAKLPLHTLRSRLSIILQDPVLFSGTIRFNLDPEKKCSDSTLWE
ALEIAQLKLVVKALPGGLDAIITEGGENFSQGQRQLFCLARAFVRKTSIF
IMDEATASIDMATENILQKVVMTAFADRTVVTIAHRVHTILSADLVMVLK
RGAILEFDKPETLLSQKDSVFASFV

3D structure

• PDB: 7tyt Ligand-mediated Structural Dynamics of a Mammalian Pancreatic K ATP Channel.
• Chain: E
• Resolution: 3.6 Å

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	BJX	E	Y377 I381 L434 L592 S595 N1245 R1246 W1297 R1300	Y369 I373 L426 L584 S587 N1092 R1093 W1144 R1147
BS02	ATP	E	W688 V715 G716 G718 K719 S720 S721 Q775	W632 V657 G658 G660 K661 S662 S663 Q695
BS03	P5S	E	I76 F79 I80 F83 V84 K227 G228 R298 F305 L368 F372 A375	I68 F71 I72 F75 V76 K219 G220 R290 F297 L360 F364 A367

Gene Ontology

Molecular Function

• GO:0005267 potassium channel activity
• GO:0005524 ATP binding
• GO:0008281 sulfonylurea receptor activity
• GO:0016887 ATP hydrolysis activity
• GO:0042626 ATPase-coupled transmembrane transporter activity
• GO:0140359 ABC-type transporter activity

Biological Process

• GO:0006813 potassium ion transport
• GO:0055085 transmembrane transport
• GO:0071805 potassium ion transmembrane transport

Cellular Component

• GO:0005886 plasma membrane
• GO:0016020 membrane
• GO:0032991 protein-containing complex

External links

• PDB: RCSB:7tyt, PDBe:7tyt, PDBj:7tyt
• PDBsum: 7tyt
• PubMed: 35964676
• UniProt: Q09427|ABCC8_CRICR ATP-binding cassette sub-family C member 8 (Gene Name=ABCC8)