Structure of PDB 7tvf Chain E

Receptor sequence
>7tvfE (length=173) Species: 9606 (Homo sapiens) [Search protein sequence]
VPSDNLPTYKLVVVGDGGVGKSALTIQFFQKIFVPDYDPTIEDSYLKHTE
IDNQWAILDVLDTAGLEEFSAMREQYMRTGDGFLIVYSVTDKASFEHVDR
FHQLILRVKDRESFPMILVANKVDLMHLRKITREQGKEMATKHNIPYIET
SAKDPPLNVDKAFHDLVRVIRQQ
3D structure
PDB7tvf Structure of the SHOC2-MRAS-PP1C complex provides insights into RAF activation and Noonan syndrome.
ChainE
Resolution2.17 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.6.5.2: small monomeric GTPase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 GNP E G23 V24 G25 K26 S27 A28 F38 V39 P40 Y42 T45 G70 K127 D129 S156 G18 V19 G20 K21 S22 A23 F33 V34 P35 Y37 T40 G65 K122 D124 S151
BS02 MG E S27 T45 S22 T40
Gene Ontology
Molecular Function
GO:0003924 GTPase activity
GO:0005525 GTP binding
Biological Process
GO:0007165 signal transduction
Cellular Component
GO:0016020 membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7tvf, PDBe:7tvf, PDBj:7tvf
PDBsum7tvf
PubMed36175670
UniProtO14807|RASM_HUMAN Ras-related protein M-Ras (Gene Name=MRAS)

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