Structure of PDB 7tve Chain E

Receptor sequence
>7tveE (length=461) Species: 580240 (Saccharomyces cerevisiae W303) [Search protein sequence]
PDLSSFQPGSIIKIRLQDFVTYTLTEFNLSPSLNMIIGPNGSGKSTFVCA
VCLGLAGKPEYIGRSKKVEDFIKNGQDVSKIEITLKNSPNVTDIEYIDAR
DETIKITRIITRSKRRSDYLINDYQVSESVVKTLVAQLNIQLDNLCQFLS
QERVEEFARLKSVKLLVETIRSIDASLLDVLDELRELQGNEQSLQKDLDF
KKAKIVHLRQESDKLRKSVESLRDFQNKKGEIELHQDVLDKLESEIAMVN
HDESAVTILDQVTAELRELEHTVPQQSKDLETIKAKLKEDHAVLEPKLDD
IVSKISARFARLFNNVGSAGAVRLEKPKDYAEWKIEIMVKFRDNAPLKKL
DSHTQSGGERAVSTVLYMIALQEFTSAPFRVVDQINQGMDSRNERIVHKA
MVENACAENTSQYFLITPKLLTGLHYHEKMRIHCVMAGSWIPNPSEDPKM
IHFGETSNYSF
3D structure
PDB7tve Cryo-EM structure of DNA-bound Smc5/6 reveals DNA clamping enabled by multi-subunit conformational changes.
ChainE
Resolution3.8 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ATP E V51 G72 G74 K75 S76 R95 Q182 P1049 V20 G41 G43 K44 S45 R64 Q151 P418
Gene Ontology
Molecular Function
GO:0003684 damaged DNA binding
GO:0003697 single-stranded DNA binding
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016887 ATP hydrolysis activity
GO:0019789 SUMO transferase activity
Biological Process
GO:0000724 double-strand break repair via homologous recombination
GO:0000725 recombinational repair
GO:0006281 DNA repair
GO:0006310 DNA recombination
GO:0007059 chromosome segregation
GO:0016925 protein sumoylation
GO:0032204 regulation of telomere maintenance
GO:0051304 chromosome separation
GO:0071139 resolution of DNA recombination intermediates
GO:0140588 chromatin looping
Cellular Component
GO:0000781 chromosome, telomeric region
GO:0005634 nucleus
GO:0005694 chromosome
GO:0030915 Smc5-Smc6 complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7tve, PDBe:7tve, PDBj:7tve
PDBsum7tve
PubMed35648833
UniProtQ08204|SMC5_YEAST Structural maintenance of chromosomes protein 5 (Gene Name=SMC5)

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