Structure of PDB 7tqv Chain E

Receptor sequence
>7tqvE (length=347) Species: 2697049 (Severe acute respiratory syndrome coronavirus 2) [Search protein sequence]
LEMSLENVAFNVVNKGHFDGQQGEVPVSIINNTVYTKVDGVDVELFENKT
TLPVNVAFELWAKRNIKPVPEVKILNNLGVDIAANTVIWDYKRDAPAHIS
TIGVCSMTDIAKKPTETICAPLTVFFDGRVDGQVDLFRNARNGVLITEGS
VKGLQPSVGPKQASLNGVTLIGEAVKTQFNYYKKVDGVVQQLPETYFTQS
RNLQEFKPRSQMEIDFLELAMDEFIERYKLEGYAFEAIVYGDFSHSQLGG
LHLLIGLAKRFKESPFELEDFIPMDSTVKNYFITDAQTGSSKCVCSVIDL
LLDDFVEIIKSQDLSVVSKVVKVTIDYTEISFMLWCKDGHVETFYPK
3D structure
PDB7tqv Flipped over U: structural basis for dsRNA cleavage by the SARS-CoV-2 endoribonuclease.
ChainE
Resolution3.43 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.1.1.56: mRNA (guanine-N(7))-methyltransferase.
2.1.1.57: methyltransferase cap1.
2.7.7.48: RNA-directed RNA polymerase.
2.7.7.50: mRNA guanylyltransferase.
3.1.13.-
3.4.19.12: ubiquitinyl hydrolase 1.
3.4.22.-
3.4.22.69: SARS coronavirus main proteinase.
3.6.4.12: DNA helicase.
3.6.4.13: RNA helicase.
4.6.1.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 rna E T113 D133 T115 D135
BS02 rna E R136 N137 R138 N139
External links
PDB RCSB:7tqv, PDBe:7tqv, PDBj:7tqv
PDBsum7tqv
PubMed35801916
UniProtP0DTD1|R1AB_SARS2 Replicase polyprotein 1ab (Gene Name=rep)

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