Structure of PDB 7tqq Chain E

Receptor sequence
>7tqqE (length=214) Species: 9606 (Homo sapiens) [Search protein sequence]
PPGPMQTLIFFDMEATGLPFSQPKVTELCLLAVHRCALESPPTPTVPPPP
RVVDKLSLCVAPGKACSPAASEITGLSTAVLAAHGRQCFDDNLANLLLAF
LRRQPQPWCLVAHNGDRYDFPLLQAELAMLGLTSALDGAFCVDSITALKA
LERRKSYSLGSIYTRLYGQSPPDSHTAEGDVLALLSICQWRPQALLRWVD
AHARPFGTIRPMYG
3D structure
PDB7tqq Structural basis of human TREX1 DNA degradation and autoimmune disease.
ChainE
Resolution2.2 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.1.11.2: exodeoxyribonuclease III.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 dna E D18 E20 A21 G23 L24 F26 A80 T85 H124 N125 Y129 R174 S176 Y177 S178 L179 D12 E14 A15 G17 L18 F20 A69 T74 H113 N114 Y118 R154 S156 Y157 S158 L159
Gene Ontology
Molecular Function
GO:0003676 nucleic acid binding
GO:0008408 3'-5' exonuclease activity

View graph for
Molecular Function
External links
PDB RCSB:7tqq, PDBe:7tqq, PDBj:7tqq
PDBsum7tqq
PubMed35879334
UniProtQ9NSU2|TREX1_HUMAN Three-prime repair exonuclease 1 (Gene Name=TREX1)

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