Structure of PDB 7tku Chain E

Receptor sequence
>7tkuE (length=348) Species: 4932 (Saccharomyces cerevisiae) [Search protein sequence]
WVDKYRPKSLNALSHNEELTNFLKSLSDQPRDLPHLLLYGPNGTGKKTRC
MALLESIFGPGVYRLKIDVRQFVTASNRKLELNVVSSPYHLEITPSDMGN
NDRIVIQELLKEVAQMEQVDFQDGLAHRYKCVIINEANSLTKDAQAALRR
TMEKYSKNIRLIMVCDSMSPIIAPIKSRCLLIRCPAPSDSEISTILSDVV
TNERIQLETKDILKRIAQASNGNLRVSLLMLESMALNNELALKSSSPIIK
PDWIIVIHKLTRKIVKERSVNSLIECRAVLYDLLAHCIPANIILKELTFS
LLDVETLNTTNKSSIIEYSSVFDERLSLGNKAIFHLEGFIAKVMCCLD
3D structure
PDB7tku Cryo-EM structures reveal high-resolution mechanism of a DNA polymerase sliding clamp loader.
ChainE
Resolution4.0 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ADP E V5 R9 P10 L16 S17 H18 G46 G48 K49 K50 T51 I201 L230 R231 V2 R6 P7 L13 S14 H15 G43 G45 K46 K47 T48 I195 L224 R225
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003689 DNA clamp loader activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016887 ATP hydrolysis activity
Biological Process
GO:0000077 DNA damage checkpoint signaling
GO:0006260 DNA replication
GO:0006261 DNA-templated DNA replication
GO:0006271 DNA strand elongation involved in DNA replication
GO:0006272 leading strand elongation
GO:0006281 DNA repair
GO:0007062 sister chromatid cohesion
GO:0007064 mitotic sister chromatid cohesion
GO:0090618 DNA clamp unloading
Cellular Component
GO:0005634 nucleus
GO:0005663 DNA replication factor C complex
GO:0031389 Rad17 RFC-like complex
GO:0031390 Ctf18 RFC-like complex
GO:0031391 Elg1 RFC-like complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7tku, PDBe:7tku, PDBj:7tku
PDBsum7tku
PubMed35179493
UniProtP38251|RFC5_YEAST Replication factor C subunit 5 (Gene Name=RFC5)

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